Department of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.
Systemic Autoimmune Diseases Research Unit, Specialties Hospital UMAE, Mexican Social Security Institute, Puebla, Mexico.
Endocr Metab Immune Disord Drug Targets. 2023;23(4):503-514. doi: 10.2174/1871530322666220908154253.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by damage to multiple systems and a higher risk of cardiovascular disease. In addition, several studies have found that insulin resistance (IR) is more prevalent in SLE patients than controls, increasing the risk of prediabetes, type 2 diabetes mellitus (T2DM) and morbidity. The objective of this review article was to summarize the most relevant evidence about the relationship among IR, T2DM and SLE, including the effects of proinflammatory states, acute-phase proteins, pro-inflammatory cytokines, and pharmacological SLE treatment. A better understanding of the mechanisms involved in these comorbidities will allow better treatment strategies.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征是多系统损伤和心血管疾病风险增加。此外，多项研究发现，SLE 患者的胰岛素抵抗（IR）比对照组更为普遍，增加了前驱糖尿病、2 型糖尿病（T2DM）和发病的风险。本文综述的目的是总结 IR、T2DM 和 SLE 之间关系的最相关证据，包括促炎状态、急性期蛋白、促炎细胞因子和药物治疗 SLE 的影响。更好地了解这些合并症的相关机制将有助于制定更好的治疗策略。
