Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Transfusion. 2022 Nov;62(11):2245-2253. doi: 10.1111/trf.17099. Epub 2022 Sep 12.
Hypotensive transfusion reaction (HyTR) is rare. It is characterized by a rapid onset of hypotension during transfusion, which usually resolves quickly upon cessation of transfusion. Information on the incidence and clinical characteristics of HyTR has been reported in only a few studies.
We retrospectively reviewed HyTR cases from 10-year hemovigilance data in a tertiary care hospital in Seoul, Korea.
We identified 37 HyTRs in 35 patients, and the overall incidence of HyTR was 0.50 per 10,000 transfused units. Among the blood components, the incidence of HyTR was highest in filtered random donor platelets (0.75 per 10,000 units). About half of the HyTRs occurred within 15 min after the start of transfusion (19/37). Blood pressure returned to the normal range within an hour in 73.0% of the cases (27/37). All HyTR cases recovered without severe complications. Known risk factors for HyTR were not prominent in our cohort of patients, with no patients taking angiotensin-converting enzyme inhibitors and only five patients transfused with bedside filtered platelets.
HyTR can occur in patients with various conditions and types of blood components. Understanding the clinical characteristics of HyTR facilitates proper management, leading to improved transfusion safety.
低血压输血反应（HyTR）较为罕见。其特点是在输血过程中迅速出现低血压，通常在停止输血后很快缓解。仅有少数研究报道了 HyTR 的发病率和临床特征方面的信息。
我们回顾性分析了韩国首尔一家三级保健医院 10 年血液监测数据中的 HyTR 病例。
我们共发现 35 名患者中的 37 例 HyTR，HyTR 的总发病率为每输注 10000 单位 0.50 例。在血液成分中，过滤随机供者血小板的 HyTR 发病率最高（每输注 10000 单位 0.75 例）。大约一半的 HyTR 发生在输血开始后 15 分钟内（19/37）。73.0%（27/37）的病例在 1 小时内血压恢复正常范围。所有 HyTR 病例均无严重并发症恢复。我们的患者队列中没有明显的 HyTR 已知危险因素，没有服用血管紧张素转换酶抑制剂的患者，仅有 5 名患者输注床边过滤血小板。
HyTR 可发生于具有各种基础疾病和输注各种血液成分的患者中。了解 HyTR 的临床特征有助于进行适当的管理，从而提高输血安全性。
