Zhuo Wen-Qing, Wen Yi, Luo Hui-Jun, Luo Zhu-Lin, Wang Li
Department of Nephrology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Front Mol Biosci. 2022 Aug 24;9:975582. doi: 10.3389/fmolb.2022.975582. eCollection 2022.
Ferroptosis is a newly identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Ferroptosis plays an essential role in the pathology of numerous diseases and has emerged as a key area of focus in studies of chronic kidney disease (CKD). CKD is a major public health problem with high incidence and mortality that is characterized by a gradual loss of kidney function over time. The severity and complexity of CKD combined with the limited knowledge of its underlying molecular mechanism(s) have led to increased interest in this disease area. Here, we summarize recent advances in our understanding of the regulatory mechanism(s) of ferroptosis and highlight recent studies describing its role in the pathogenesis and progression of CKD. We further discuss the potential therapeutic benefits of targeting ferroptosis for the treatment of CKD and the major hurdles to overcome for the translation of studies into the clinic.
铁死亡是一种新发现的受调控的细胞死亡形式，其特征是铁积累和脂质过氧化。铁死亡在多种疾病的病理过程中起着至关重要的作用，并已成为慢性肾脏病（CKD）研究的一个关键重点领域。CKD是一个主要的公共卫生问题，发病率和死亡率都很高，其特征是肾功能随时间逐渐丧失。CKD的严重性和复杂性，加上对其潜在分子机制的了解有限，导致了对该疾病领域的兴趣增加。在这里，我们总结了我们对铁死亡调控机制理解的最新进展，并强调了描述其在CKD发病机制和进展中作用的最新研究。我们进一步讨论了针对铁死亡治疗CKD的潜在治疗益处，以及将研究转化为临床应用需要克服的主要障碍。
