Paidisetty Prakrut, Nagose Vaishali, Vaze Vikrant, Mahajan Neha, Rathod Shivanand
Dr Ulhas Patil Medical College and Hospital, Jalgaon, Maharashtra India.
Department of Pathology, Dr Ulhas Patil Medical College and Hospital, Jalgaon, Maharashtra India.
Indian J Microbiol. 2022 Dec;62(4):602-609. doi: 10.1007/s12088-022-01038-5. Epub 2022 Sep 5.
To analyze the clinic-pathological profile of patients presenting with mucormycosis infection to a tertiary care center during the second wave of the COVID-19 pandemic in India. This descriptive cross-sectional study was conducted in a hospital setting from April 2021 to July 2021 and analysis was carried out to find associations between the stratified data and the extent of the disease involvement based on radiological findings. Statistical tests like percentage, average, chi-square test, etc. were used wherever relevant using software called Minitab13. All the 51 patients had involvement of at least one paranasal sinus. The incidence of previously established risk factors was diabetes (66.67%), history of severe COVID-19 disease (5.88%), raised serum iron levels (1.96%), Acidosis (3.92%), steroid administration (62.75%), oxygen administration (25.49%). Elevated serum urea levels (76.47%), alkalosis in 50.98% and hyperglycemia on multiple occasions (41.17%) were observed. The mean days between start of treatment for COVID-19 and appearance of first symptom suggesting mucormycosis were found to be 27.59 days. Only in 5.88% participants mucormycosis preceded COVID-19 infection detection. The current work finds presence of traditional risk factors and associations in significantly lower frequencies than the reviewed literature. However, blood urea was elevated in three fourths of the participants. Larger scale studies in mucormycosis patients are warranted for finding the role of other risk factors including possible role of elevated blood urea and hyperglycemia in the present era.
分析在印度第二波新冠疫情期间，前往一家三级医疗中心就诊的毛霉菌病感染患者的临床病理特征。这项描述性横断面研究于2021年4月至2021年7月在医院环境中进行，并基于放射学检查结果对分层数据与疾病累及范围之间的关联进行分析。在相关情况下使用百分比、平均值、卡方检验等统计检验方法，借助名为Minitab13的软件进行分析。所有51例患者均至少累及一个鼻窦。既往已确定的危险因素发生率为：糖尿病（66.67%）、重症新冠疾病史（5.88%）、血清铁水平升高（1.96%）、酸中毒（3.92%）、使用类固醇（62.75%）、吸氧（25.49%）。观察到血清尿素水平升高（76.47%）、碱中毒（50.98%）以及多次出现高血糖（41.17%）。发现新冠治疗开始至出现提示毛霉菌病的首个症状之间的平均天数为27.59天。仅5.88%的参与者毛霉菌病先于新冠感染被发现。当前研究发现，传统危险因素及其关联的出现频率显著低于已发表文献。然而，四分之三的参与者血尿素升高。有必要对毛霉菌病患者开展更大规模的研究，以明确包括血尿素升高和高血糖在当前时代可能发挥的作用在内的其他危险因素的作用。
