Nayaka Basavanthappa Prahlada, Narayana Murthy C, Nandyal Sonam S, Radhika T M
Department of ENT-Head and Neck surgery, Skull base surgery, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka 577501 India.
Department of Pathology, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka 577501 India.
Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):1857-1861. doi: 10.1007/s12070-023-04428-3. Epub 2023 Dec 19.
Coronavirus disease 2019 attributed to severe acute respiratory syndrome has been implicated with life threatening opportunistic infections like mucormycosis. COVID-19 is a hyperferritinemic syndrome and emerging data project the role of iron in the susceptibility and pathogenesis of mucormycosis but whether high ferritin is an indicator of severity of mucormycosis is debated. The study aimed to determine the relationship between serum ferritin levels and the extent of involvement of COVID-19 associated mucormycosis. A hospital based observational study was conducted with a sample size of 70. All biopsy confirmed cases of COVID-19 associated mucormycosis were included. Retrospective data from hospital records prepared at the time of patient admission were retrieved. The imaging data was used to determine the extent of disease involvement and serum ferritin values were analysed. During the study period 40 patients had mild extent mucormycosis and 30 had severe extent. A statistically significant difference was seen in levels of serum ferritin between mild extent mucormycosis and severe extent involvement (p < 0.01). COVID-19 associated Mucormycosis patients tend to have higher serum ferritin values especially in severe extent disease and with active COVID-19 infection along with diabetes mellitus as a potent aggravating factor.
2019年冠状病毒病（归因于严重急性呼吸综合征）已被认为与毛霉菌病等危及生命的机会性感染有关。新型冠状病毒肺炎是一种高铁蛋白血症综合征，新出现的数据表明铁在毛霉菌病的易感性和发病机制中起作用，但高铁蛋白是否是毛霉菌病严重程度的指标仍存在争议。本研究旨在确定血清铁蛋白水平与新型冠状病毒肺炎相关毛霉菌病的受累程度之间的关系。开展了一项基于医院的观察性研究，样本量为70例。纳入所有经活检确诊的新型冠状病毒肺炎相关毛霉菌病病例。检索患者入院时所制备医院记录中的回顾性数据。利用影像学数据确定疾病受累程度，并分析血清铁蛋白值。在研究期间，40例患者患有轻度毛霉菌病，30例患有重度毛霉菌病。轻度毛霉菌病和重度受累之间的血清铁蛋白水平存在统计学显著差异（p＜0.01）。新型冠状病毒肺炎相关毛霉菌病患者往往具有较高的血清铁蛋白值，尤其是在疾病重度阶段，以及在新型冠状病毒肺炎感染活跃且伴有糖尿病这一强效加重因素的情况下。
