在墨西哥使用抗病毒药物1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（利巴韦林）的临床经验。

Clinical experiences using the antiviral 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) in Mexico.

作者信息

Zertuche H F, Perches R D

出版信息

Ann N Y Acad Sci. 1977 Mar 4;284:284-8. doi: 10.1111/j.1749-6632.1977.tb21962.x.

DOI:10.1111/j.1749-6632.1977.tb21962.x

Abstract

Follow-up of the use of ribavirin in 390 human patients in Mexico indicates the drug has been used to treat a variety of virus infections. No toxic manifestations of the drug were reported, and the subjective results suggest possible antiviral efficacy. A double-blind, placebo-controlled study using topically applied 5% ribavirin in ointment base against herpes zoster in cancer patients indicates definite efficacy against this specific disease.

摘要

对墨西哥390名人类患者使用利巴韦林的随访表明，该药物已被用于治疗多种病毒感染。未报告该药物的毒性表现，主观结果表明可能具有抗病毒疗效。一项针对癌症患者的带状疱疹，使用含5%利巴韦林的软膏基质进行局部应用的双盲、安慰剂对照研究表明，该药物对这种特定疾病具有确切疗效。