基于超声驱动植入物的按需电化学控制化合物释放
On-demand electrochemically controlled compound release from an ultrasonically powered implant.
作者信息
Wang Max L, Chamberlayne Christian F, Xu Haixia, Mofidfar Mohammad, Baltsavias Spyridon, Annes Justin P, Zare Richard N, Arbabian Amin
机构信息
Department of Electrical Engineering, Stanford University Stanford CA USA
Department of Chemistry, Stanford University Stanford CA USA.
出版信息
RSC Adv. 2022 Aug 17;12(36):23337-23345. doi: 10.1039/d2ra03422k. eCollection 2022 Aug 16.
On-demand drug delivery systems are promising for a wide range of therapeutic applications. When combined with wireless implants for controlled drug delivery, they can reduce overall dosage and side effects. Here, we demonstrate release of fluorescein from a novel on-demand release system for negatively charged compounds. The release system is based on a modified electroresponsive polypyrrole nanoparticulate film designed to minimize ion exchange with the stored compound - a major passive leakage mechanism. We further designed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system . Release kinetics are characterized both and in mice using fluorescein as a model drug, demonstrating the feasibility of wireless, controllable drug release using an ultrasonically powered implant.
按需给药系统在广泛的治疗应用中具有广阔前景。当与用于控释药物的无线植入物相结合时，它们可以减少总体剂量和副作用。在此，我们展示了一种用于带负电荷化合物的新型按需释放系统中荧光素的释放。该释放系统基于一种经过改性的电响应性聚吡咯纳米颗粒薄膜，其设计目的是尽量减少与储存化合物的离子交换——这是一种主要的被动泄漏机制。我们还设计了一种由超声波驱动的毫米级植入物，以电子方式控制按需给药系统。以荧光素作为模型药物，在体外和小鼠体内对释放动力学进行了表征，证明了使用由超声波驱动的植入物实现无线、可控药物释放的可行性。
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