Yang Yulu, Zhu Yafei
Department of Pediatrics, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Department of Neonatology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Pediatr. 2022 Aug 25;10:989193. doi: 10.3389/fped.2022.989193. eCollection 2022.
This paper studied the Epstein-Barr virus (EBV) infection status and influencing factors among children using a combined detection of specific antibodies and DNA.
We retrospectively analyzed children who visited the Affiliated Hospital of Hangzhou Normal University from January 2019 to December 2020, and correlations between the social environment and clinical data were analyzed.
The cumulative positive rates of specific antibody, DNA, and combined detection of EBV were 52.4%, 39.5%, and 54.0% ( = 0.001), respectively. The current infection rate was 15.7%, and the peak of infection occurred in the preschool group ( = 0.021). After adjusting for confounding factors, the number of siblings ( = 1.550) and family members who smoke ( = 1.524) were independent risk factors for EBV infection, whereas parents with a higher education level = 0.493, = 0.316), longer breastfeeding time ( = 0.578) and dedicated tableware ( = 0.573) were independent protective factors.
A combination of antibody and DNA tests may be beneficial for the diagnosis of EBV infection. The EBV infection rate in children at our hospital was lower than the national average. Furthermore, the infection rate is closely related to the number of siblings, regardless of whether family members smoke, the status of parents' education, breastfeeding duration, and meal patterns. Overall, prevention measures should focus on the preschoolers.
本文采用特异性抗体和DNA联合检测方法，研究儿童EB病毒（EBV）感染状况及其影响因素。
回顾性分析2019年1月至2020年12月在杭州师范大学附属医院就诊的儿童，并分析社会环境与临床资料之间的相关性。
EBV特异性抗体、DNA及联合检测的累积阳性率分别为52.4%、39.5%和54.0%（P = 0.001）。当前感染率为15.7%，感染高峰出现在学龄前儿童组（P = 0.021）。调整混杂因素后，同胞数量（P = 1.550）和家庭成员吸烟情况（P = 1.524）是EBV感染的独立危险因素，而父母受教育程度较高（P = 0.493，P = 0.316）、母乳喂养时间较长（P = 0.578）和使用专用餐具（P = 0.573）是独立保护因素。
抗体和DNA检测联合应用可能有助于EBV感染的诊断。我院儿童EBV感染率低于全国平均水平。此外，感染率与同胞数量密切相关，与家庭成员是否吸烟、父母教育状况、母乳喂养持续时间和用餐模式无关。总体而言，预防措施应重点针对学龄前儿童。
