Beader Nataša, Kolarić Branko, Slačanac Domagoj, Tabain Irena, Vilibić-Čavlek Tatjana
Department of Microbiology, School of Medicine, University of Zagreb, Zagreb, Croatia.
Department of Clinical and Molecular Microbiology, University Hospital Centre Zagreb, Zagreb, Croatia.
Isr Med Assoc J. 2018 Feb;20(2):86-90.
The Epstein-Barr virus (EBV) is one of the most common viruses found in humans, causing lifelong infection in up to 95% of the world population.
To analyze the seroprevalence of EBV infection in different population groups in Croatia.
During a 2 year period (2015-2016), a total of 2022 consecutive serum samples collected from Croatian residents were tested for the presence of EBV-specific viral capsid antigen (VCA) immunoglobulin M (IgM) and IgG antibodies using an enzyme-linked immunoassay. IgM/IgG-positive samples were further tested for IgG avidity.
The overall prevalence of EBV IgG antibodies was 91.4%. Females had significantly higher IgG seroprevalence than males (93.1% vs. 89.9%, P = 0.008). According to age, IgG seropositivity increased progressively from 59.6% in children age < 9 years to 98.3% in 30-39 year olds, and remained stable thereafter (P < 0.001). The IgG seroprevalence differed significantly among groups: 68.1% in children/adolescents and 95.9% in adults; multiple sclerosis (100%), hemodialysis patients (97.7%), heart transplant recipients (93.8%), hematological malignancies (91.2%), and Crohn's disease (88.5%), P < 0.001. IgM antibodies were detected in 9% of participants. Using IgG avidity, recent primary EBV infection was documented in 83.8% of IgM-positive subjects < 9 years old, 69.2% age 10-19, 33.3% age 20-29, and 3.6-4.2% > 40. All IgM positive participants > 40 years showed high IgG avidity. Logistic regression showed that age is associated with EBV IgG seropositivity.
EBV is widespread in the Croatian population. Older age appears to be the main risk factor for EBV seropositivity.
爱泼斯坦-巴尔病毒（EBV）是人类最常见的病毒之一，全球高达95%的人口会受到其终身感染。
分析克罗地亚不同人群中EBV感染的血清流行率。
在2年期间（2015 - 2016年），使用酶联免疫吸附测定法对从克罗地亚居民中连续采集的2022份血清样本进行检测，以确定是否存在EBV特异性病毒衣壳抗原（VCA）免疫球蛋白M（IgM）和IgG抗体。对IgM/IgG阳性样本进一步检测IgG亲和力。
EBV IgG抗体的总体流行率为91.4%。女性的IgG血清流行率显著高于男性（93.1%对89.9%，P = 0.008）。按年龄划分，IgG血清阳性率从9岁以下儿童的59.6%逐渐上升至30 - 39岁人群的98.3%，此后保持稳定（P < 0.001）。IgG血清流行率在不同组间存在显著差异：儿童/青少年为68.1%，成人为95.9%；多发性硬化症患者（100%）、血液透析患者（97.7%）、心脏移植受者（93.8%）、血液系统恶性肿瘤患者（91.2%）和克罗恩病患者（88.5%），P < 0.001。9%的参与者检测到IgM抗体。通过IgG亲和力检测，9岁以下IgM阳性受试者中83.8%、10 - 19岁者中69.2%、20 - 29岁者中33.3%以及40岁以上者中3.6 - 4.2%被记录为近期原发性EBV感染。所有40岁以上的IgM阳性参与者均显示高IgG亲和力。逻辑回归分析表明年龄与EBV IgG血清阳性相关。
EBV在克罗地亚人群中广泛存在。年龄较大似乎是EBV血清阳性的主要危险因素。
