Bratteteig Mari, Anderssen Sigmund Alfred, Rueegg Corina Silvia, Ruud Ellen, Torsvik Ingrid Kristin, Kriemler Susi, Grydeland May
Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Front Pediatr. 2022 Aug 25;10:977365. doi: 10.3389/fped.2022.977365. eCollection 2022.
We aimed to compare cardiovascular disease (CVD) risk factors in childhood cancer survivors (CCS) with age- and sex-stratified reference material and examine the association between physical activity (PA) intensities and CVD risk factors in CCS.
Within the cross-sectional, multicenter (PACCS) study, we collected data on CVD risk factors [VO (mL⋅kg⋅min), body mass index (BMI, kg/m), systolic blood pressure (SBP, mmHg), and total-cholesterol/HDL-cholesterol (Total/HDL)] among CCS aged 9-18 years. CVD risk factors were compared to references with immediate -tests. We transformed CVD risk factors into -scores based on international references and generated an individual CVD risk score: [inverse ZVO + Z + Z + Z )/4]. Multivariable mixed linear regression models were used to analyze the associations between device-measured PA intensities and CVD risk factors.
We included 157 CCS aged on average 13.4 years at inclusion and 8.2 years from diagnosis. Male CCS had lower VO compared to references (45.4 vs. 49.4 mL⋅kg⋅min, = 0.001), higher diastolic BP (67 vs. 63 mmHg, < 0.001), lower HDL (1.35 vs. 1.44 mmol/L, = 0.012), as well as a tendency to higher CVD risk score (-score=0.14 vs. 0.00, = .075). Female CCS' CVD risk factors were comparable to references. Vigorous-intensity PA (VPA) was associated with CVD risk factors. A 10-min increase in VPA was associated with higher VO (β = 4.9, 95% CI, 2.1-7.7), lower Total/HDL (β = -0.3, 95% CI, -0.6 to -0.1) and a lower CVD risk score (β = -0.4, 95% CI, -0.6 to -0.2).
Male adolescent CCS had less favorable values of CVD risk factors compared to references. VPA in adolescent CCS is associated with clinically meaningful favorable values of CVD risk factors.
我们旨在将儿童癌症幸存者（CCS）的心血管疾病（CVD）危险因素与年龄和性别分层的参考资料进行比较，并研究CCS中身体活动（PA）强度与CVD危险因素之间的关联。
在横断面多中心（PACCS）研究中，我们收集了9至18岁CCS的CVD危险因素数据[VO₂（mL·kg⁻¹·min⁻¹）、体重指数（BMI，kg/m²）、收缩压（SBP，mmHg）和总胆固醇/高密度脂蛋白胆固醇（Total/HDL）]。通过即时检验将CVD危险因素与参考资料进行比较。我们根据国际参考资料将CVD危险因素转换为z分数，并生成个体CVD风险评分：[逆ZVO₂ + ZBMI + ZSBP + ZTotal/HDL）/4]。使用多变量混合线性回归模型分析设备测量的PA强度与CVD危险因素之间的关联。
我们纳入了平均年龄为13.4岁（入组时）且自诊断后8.2年的157例CCS。与参考资料相比，男性CCS的VO₂较低（45.4对49.4 mL·kg⁻¹·min⁻¹，P = 0.001），舒张压较高（67对63 mmHg，P < 0.001），高密度脂蛋白较低（1.35对1.44 mmol/L，P = 0.012），并且有CVD风险评分较高的趋势（z分数=0.14对0.00，P = 0.075）。女性CCS的CVD危险因素与参考资料相当。剧烈强度PA（VPA）与CVD危险因素相关。VPA每增加10分钟与较高的VO₂（β = 4.9，95%CI，2.1 - 7.7）、较低的Total/HDL（β = -0.3，95%CI，-0.6至-0.1）和较低的CVD风险评分（β = -0.4，95%CI，-0.6至-0.2）相关。
与参考资料相比，男性青少年CCS的CVD危险因素值不太理想。青少年CCS中的VPA与具有临床意义的有利CVD危险因素值相关。
