Slater Megan E, Ross Julie A, Kelly Aaron S, Dengel Donald R, Hodges James S, Sinaiko Alan R, Moran Antoinette, Lee Jill, Perkins Joanna L, Chow Lisa S, Baker K Scott, Steinberger Julia
University of Minnesota, Minneapolis, Minnesota.
Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota.
Pediatr Blood Cancer. 2015 Feb;62(2):305-310. doi: 10.1002/pbc.25276. Epub 2014 Oct 18.
Childhood cancer survivors (CCS) are at high risk of developing treatment-related late effects, including cardiovascular disease and diabetes. Late effects can be exacerbated by low physical activity (PA) levels. Relationships between PA and cardiovascular risk factors during childhood have not been well described in CCS.
PA and cardiovascular risk factors were measured cross-sectionally in 319 CCS and 208 sibling controls aged 9-18 years. Comparisons between CCS and controls and associations of outcomes with PA (dichotomized at 60 min/day or treated as continuous) were performed with linear regression.
Among CCS, the high PA group had lower percent fat mass (24.4% vs. 29.8%, P < 0.0001), abdominal subcutaneous fat (67.9 vs. 97.3 cm , P = 0.0004), and abdominal visceral fat (20.0 vs. 24.9 cm , P = 0.007) and greater lean body mass (41.3 vs. 39.5 kg, P = 0.009) than the low PA group. Comparing CCS to controls, differences in waist circumference (P = 0.04), percent fat mass (P = 0.04), and abdominal subcutaneous (P = 0.02) and visceral (P = 0.004) fat between low and high PA groups were greater in CCS than controls, possibly due to greater overall adiposity in CCS.
High PA in CCS resulted in an improved cardiovascular profile, consisting primarily of lower fat mass and greater lean mass, similar to that observed in controls. This suggests interventions directed to increase PA in CCS may reduce the risk of future cardiovascular disease. Pediatr Blood Cancer 2015;62:305-310. © 2014 Wiley Periodicals, Inc.
儿童癌症幸存者（CCS）发生与治疗相关的晚期效应（包括心血管疾病和糖尿病）的风险很高。身体活动（PA）水平低会加剧晚期效应。在CCS中，儿童期PA与心血管危险因素之间的关系尚未得到充分描述。
对319名9至18岁的CCS和208名同胞对照进行了PA和心血管危险因素的横断面测量。使用线性回归对CCS与对照之间进行比较，并将结果与PA（以每天60分钟进行二分法划分或视为连续变量）进行关联分析。
在CCS中，高PA组的体脂百分比（24.4%对29.8%，P<0.0001）、腹部皮下脂肪（67.9对97.3平方厘米，P=0.0004）和腹部内脏脂肪（20.0对24.9平方厘米，P=0.007）低于低PA组，而瘦体重（41.3对39.5千克，P=0.009）高于低PA组。将CCS与对照进行比较，低PA组和高PA组之间腰围（P=0.04）、体脂百分比（P=0.04）以及腹部皮下（P=0.02）和内脏（P=0.004）脂肪的差异在CCS中比对照中更大，这可能是由于CCS总体肥胖程度更高。
CCS中的高PA导致心血管状况改善，主要表现为较低的脂肪量和较高的瘦体重，与在对照中观察到的情况相似。这表明针对增加CCS中PA的干预措施可能会降低未来心血管疾病的风险。《儿科血液与癌症》2015年；62：305 - 310。©2014威利期刊公司
