精准医学时代癌症全程生物标志物应用的考量
Considerations of biomarker application for cancer continuum in the era of precision medicine.
作者信息
Hung Rayjean J, Khodayari Moez Elham, Kim Shana J, Budhathoki Sanjeev, Brooks Jennifer D
机构信息
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
出版信息
Curr Epidemiol Rep. 2022 Sep;9(3):200-211. doi: 10.1007/s40471-022-00295-8. Epub 2022 Jul 9.
Abstract
PURPOSE OF THE REVIEW
The goal of this review is to highlight emerging biomarker research by the key phases of the cancer continuum and outline the methodological considerations for biomarker application.
RECENT FINDINGS
While biomarkers have an established role in targeted therapy and to some extent, disease monitoring, their role in early detection and survivorship remains to be elucidated. With the advent of omics technology, the discovery of biomarkers has been accelerated exponentially, therefore careful consideration to ensure an unbiased study design and robust validity is crucial.
SUMMARY
The rigor of biomarker research holds the key to the success of precision health care. The potential clinical utility and the feasibility of implementation should be central to future biomarker research study design.
摘要
综述目的
本综述的目的是强调癌症连续统一体关键阶段中新兴的生物标志物研究，并概述生物标志物应用的方法学考量。
最新发现
虽然生物标志物在靶向治疗以及在一定程度上疾病监测中已确立了作用，但其在早期检测和生存方面的作用仍有待阐明。随着组学技术的出现，生物标志物的发现呈指数级加速，因此仔细考虑以确保无偏倚的研究设计和强大的有效性至关重要。
总结
生物标志物研究的严谨性是精准医疗成功的关键。潜在的临床实用性和实施的可行性应成为未来生物标志物研究设计的核心。
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