Łukasik Adriana, Kozicka Karolina, Pisarek Aleksandra, Wojas-Pelc Anna
Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland.
Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Postepy Dermatol Alergol. 2022 Aug;39(4):708-713. doi: 10.5114/ada.2021.108429. Epub 2021 Aug 16.
Androgenetic alopecia is the most common type of non-cicatricial alopecia both in male and female patients. The mechanism that leads to hair loss is similar in both sexes, but the underlying cause, and especially the role of genes and sex hormones in the pathogenesis of the disease in women has not fully been explained as of yet. So far, a few attempts have been made to assess selected SNPs for and genes, but their results are not unequivocal and fully reproducible.
To investigate the association of 13 and 11 gene SNPs with female androgenetic alopecia (FAGA) in a population of Polish patients, including some already genotyped SNPs of possible importance for FAGA pathophysiology in other populations.
Twenty-four genetic polymorphisms were analysed for the and genes in 117 patients with FAGA and 128 healthy subjects treated at the Department of Dermatology in Krakow.
In the studied Polish population, none of the selected SNPs, frequently detected in the Caucasian population and linked with the transformation pathway of sex hormones, showed a significant association with FAGA.
Further studies into the genetic background of androgenetic alopecia are needed. Ethnic differences as well as the size of the studied population may be of great significance for the obtained results.
雄激素性脱发是男性和女性患者中最常见的非瘢痕性脱发类型。导致脱发的机制在两性中相似，但潜在原因，尤其是基因和性激素在女性该疾病发病机制中的作用尚未得到充分解释。到目前为止，已经尝试评估了某些与 和 基因相关的单核苷酸多态性（SNP），但其结果并不明确且无法完全重复。
在波兰患者群体中研究13个 基因和11个 基因的SNP与女性雄激素性脱发（FAGA）的关联，包括一些在其他群体中对FAGA病理生理学可能具有重要意义且已进行基因分型的SNP。
对克拉科夫皮肤科治疗的117例FAGA患者和128例健康受试者的 和 基因分析了24种基因多态性。
在研究的波兰人群中，在白种人群体中经常检测到的、与性激素转化途径相关的选定SNP，均未显示与FAGA有显著关联。
需要对雄激素性脱发的遗传背景进行进一步研究。种族差异以及研究人群的规模可能对所得结果具有重要意义。
