Pietraszek M H, Buczko W
Eur J Pharmacol. 1987 Jun 4;137(2-3):273-5. doi: 10.1016/0014-2999(87)90235-4.
The effect of verapamil on 5-hydroxytryptamine (5HT) uptake into rat blood platelets was investigated in vitro. Verapamil produced a non-competitive inhibition (IC50 = 8.2 +/- 0.5 microM) of 5HT uptake. The administration of verapamil to rats also produced inhibition of 5HT uptake and reduced the concentration of this amine in the platelets. The present data indicate that verapamil has an influence on the uptake processes for 5HT in blood platelets in rats.
在体外研究了维拉帕米对5-羟色胺（5HT）摄入大鼠血小板的影响。维拉帕米对5HT的摄入产生非竞争性抑制（IC50 = 8.2±0.5微摩尔）。给大鼠施用维拉帕米也抑制了5HT的摄入，并降低了血小板中这种胺的浓度。目前的数据表明，维拉帕米对大鼠血小板中5HT的摄取过程有影响。
