Costa J L, Kirk K L
Res Commun Chem Pathol Pharmacol. 1979 Jul;25(1):79-88.
Employing C14-glucose and C14-serotonin (5HT) as precursors, we have synthesized desoxyfructo-5HT [1-desoxy-1-(5-hydroxytryptamine)-D-fructose] labelled either in the sugar or 5HT moieties, and examined the uptake of the labelled substrate by washed human platelets. Desoxyfructo-5HT appears to interact with the 5HT uptake site, effectively inhibiting the uptake of H3-5HT. However, our data indicate that contrary to published reports, the entry of desoxyfructo-5HT into platelet vesicles or cytoplasm is negligible.
我们以C14 - 葡萄糖和C14 - 血清素（5 - 羟色胺，5HT）作为前体，合成了糖部分或5HT部分带有标记的脱氧果糖 - 5HT [1 - 脱氧 - 1 -（5 - 羟色胺）- D - 果糖]，并检测了洗涤过的人血小板对标记底物的摄取情况。脱氧果糖 - 5HT似乎与5HT摄取位点相互作用，有效抑制了H3 - 5HT的摄取。然而，我们的数据表明，与已发表的报告相反，脱氧果糖 - 5HT进入血小板囊泡或细胞质的量可忽略不计。
