Chen Xindong, Zhou Zhiruo, Zhang Zhi, Zhao Chenhao, Li Jiayu, Jiang Jingwen, Huang Biao, Qin Yuan
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou, China.
Front Pharmacol. 2022 Aug 25;13:969422. doi: 10.3389/fphar.2022.969422. eCollection 2022.
Puerarin is a flavonoid molecule that widely exists in various plants. Puerarin has been reported to exhibit anti-tumor effects in various cancers. However, its exact underlying pharmacological mechanism is unclear. This study evaluated the anticancer effect of puerarin combined with oxaliplatin (OXA) and . Our results indicated that puerarin can reverse platinum-based anti-cancer drug resistance, and enhance the OXA's anticancer effects on breast cancer. Furthermore, puerarin can inhibit migration and reverse the epithelial-mesenchymal transition (EMT) induced by low-dose OXA. Further studies showed that the carbonic anhydrase (CA) XII is a potential target of puerarin. In conclusion, puerarin is expected to become an adjuvant chemotherapy drug and potentially become one of the medicated foods for breast cancer patients.
葛根素是一种广泛存在于各种植物中的黄酮类分子。据报道，葛根素在多种癌症中具有抗肿瘤作用。然而，其确切的潜在药理机制尚不清楚。本研究评估了葛根素联合奥沙利铂（OXA）的抗癌效果。我们的结果表明，葛根素可以逆转铂类抗癌药物耐药性，并增强奥沙利铂对乳腺癌的抗癌作用。此外，葛根素可以抑制低剂量奥沙利铂诱导的迁移并逆转上皮-间质转化（EMT）。进一步研究表明，碳酸酐酶（CA）XII是葛根素的一个潜在靶点。总之，葛根素有望成为一种辅助化疗药物，并有可能成为乳腺癌患者的食疗药物之一。
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