Bowler S D, Mitchell C A, Armstrong J G, Scicchitano R
Eur J Respir Dis. 1987 May;70(5):280-3.
We investigated the bronchodilator effect of intravenous aminophylline given after a cumulative dose of nebulized fenoterol of 2.4 mg in 18 patients with acute severe asthma. The mean forced expiratory volume in 1 s (FEV1) +/- SD before treatment was 0.72 +/- 0.22 l. The mean improvement in FEV1 after fenoterol was 0.64 +/- 0.39 l (85% of total improvement) and after aminophylline 0.11 +/- 0.13 l (15% of total improvement). The improvement after aminophylline was statistically significant (p less than 0.01), though quantitatively small. Thirteen patients improved after aminophylline by less than 0.15 l, and in only five was the improvement 0.2-0.4 l. There was no significant change in heart rate and subjective tremor score with treatment, although observed tremor (0 = absent, 4 = maximum) increased from 0.4 +/- 0.6 to 1.3 +/- 1.0 after all treatment. For the majority of patients presenting with acute severe asthma, it is likely that high doses of nebulized beta-2 agonist alone will produce near maximal bronchodilation in the short term.
我们研究了18例急性重症哮喘患者在雾化吸入累计剂量为2.4mg非诺特罗后静脉注射氨茶碱的支气管扩张作用。治疗前1秒用力呼气容积（FEV1）的平均值±标准差为0.72±0.22升。非诺特罗治疗后FEV1的平均改善值为0.64±0.39升（占总改善值的85%），氨茶碱治疗后为0.11±0.13升（占总改善值的15%）。氨茶碱治疗后的改善具有统计学意义（p<0.01），尽管在量上较小。13例患者在使用氨茶碱后改善值小于0.15升，只有5例患者的改善值为0.2 - 0.4升。治疗过程中心率和主观震颤评分无显著变化，尽管观察到的震颤（0 = 无，4 = 最大）在所有治疗后从0.4±0.6增加到1.3±1.0。对于大多数急性重症哮喘患者，短期内单独使用高剂量雾化β2激动剂可能会产生接近最大程度的支气管扩张。
