Inoue Yu, Hasebe Yuichi, Igarashi Toshio, Kawagishi-Hotta Mika, Okuno Ryosuke, Yamada Takaaki, Hasegawa Seiji
Research Laboratories Nippon Menard Cosmetic Co., Ltd Nagoya Aichi Japan.
Nagoya University-MENARD Collaborative Research Chair Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Skin Health Dis. 2022 Apr 1;2(3):e110. doi: 10.1002/ski2.110. eCollection 2022 Sep.
Stress may have various effects on our bodies. In particular, the skin may be readily influenced by stress. In addition, there are individual differences in the way we feel stress, suggesting the involvement of genetic factors in such individual differences.
In this study, we analysed the influence of stress on skin condition and ageing involving Japanese females, and investigated single nucleotide polymorphisms (SNPs) that influence perceived stress of an individual.
We collected genotype data from 1200 Japanese females. At the same time, a questionnaire was conducted on the degree of stress that each subject feels on a daily basis and the current skin condition. We analysed the effects of stress on skin condition and searched for SNPs related to individual stress susceptibility by genome-wide association studies.
Our data suggested that stress influences skin condition and ageing, as previously reported. And, we found rs74548608 as a SNP that affects perceived stress of an individual. This SNP is located on the upstream of Patched-1, which is a gene that functions as a sonic hedgehog receptor.
Our study has identified new genetic factors for perceived stress of an individual in the Japanese female. The SNP found in this study may be a candidate factor important for understanding the perceived stress of an individual of Japanese.
压力可能对我们的身体产生多种影响。特别是，皮肤可能很容易受到压力的影响。此外，我们感受压力的方式存在个体差异，这表明遗传因素参与了这些个体差异。
在本研究中，我们分析了压力对日本女性皮肤状况和衰老的影响，并研究了影响个体感知压力的单核苷酸多态性（SNP）。
我们收集了1200名日本女性的基因型数据。同时，对每个受试者每天感受到的压力程度和当前皮肤状况进行了问卷调查。我们分析了压力对皮肤状况的影响，并通过全基因组关联研究寻找与个体压力易感性相关的SNP。
我们的数据表明，压力会影响皮肤状况和衰老，正如先前报道的那样。而且，我们发现rs74548608是一个影响个体感知压力的SNP。该SNP位于Patched-1的上游，Patched-1是一种作为音猬因子受体发挥作用的基因。
我们的研究确定了日本女性个体感知压力的新遗传因素。本研究中发现的SNP可能是理解日本个体感知压力的一个重要候选因素。
