Källander C F, Simonsson B, Gronowitz J S, Nilsson K
Eur J Haematol. 1987 Apr;38(4):331-7. doi: 10.1111/j.1600-0609.1987.tb00007.x.
The serum thymidine kinase (S-TK) and proliferative activity of the leukemic cells were determined in 27 untreated patients with chronic lymphocytic leukemia (CLL). A significant positive correlation between S-TK and proliferation expressed as a proliferative index (PI) was found (r = 0.70, p less than 0.001). Additionally, PI (r = 0.59, p less than 0.01) and S-TK (r = 0.47, p less than 0.05) correlated to peripheral blood lymphocyte count. When different variables and combinations of variables were studied in order to define their capacity for discriminating between progressive and indolent CLL, S-TK activity and PI proved to be powerful indications. In longitudinal studies, both S-TK and PI paralleled disease activity. A model where a combination of S-TK and PI gives information of the degree of localized disease is proposed.
对27例未经治疗的慢性淋巴细胞白血病（CLL）患者测定了血清胸苷激酶（S-TK）和白血病细胞的增殖活性。发现S-TK与以增殖指数（PI）表示的增殖之间存在显著正相关（r = 0.70，p < 0.001）。此外，PI（r = 0.59，p < 0.01）和S-TK（r = 0.47，p < 0.05）与外周血淋巴细胞计数相关。为了确定不同变量及变量组合区分进展性和惰性CLL的能力而进行研究时，S-TK活性和PI被证明是有力的指标。在纵向研究中，S-TK和PI均与疾病活动平行。提出了一个模型，其中S-TK和PI的组合可提供局部疾病程度的信息。
