Satyanarayana Acharyulu Narayanam Phani, Sohan Arya, Banoth Pravallika, Chintalapati Srinivasu, Doshi Sejal, Reddy Venu, Santhosh Chella, Grace Andrews Nirmala, De Los Santos Valladares Luis, Kollu Pratap
Department of Physics, Krishna University, Machilipatnam, Andhra Pradesh 521003, India.
Department of Engineering Physics, S.R.K.R. Engineering College, West Godavari District, Bhimavaram, Andhra Pradesh 534204, India.
ACS Omega. 2022 Aug 25;7(35):30794-30800. doi: 10.1021/acsomega.2c02064. eCollection 2022 Sep 6.
Recent investigations have demonstrated that nickel ferrite nanoparticles and their derivatives have toxicity effects on bacterial cells. In this study, we have prepared nickel ferrite nanoparticles (Ni/NiFeO) and nickel/nickel ferrite graphene oxide (Ni/NiFeO-GO) nanocomposite and evaluated their toxic effects on cells ATCC 25922. The prepared nanomaterials were characterized using X-ray diffraction, Raman spectroscopy, scanning electron microscopy, transmission electron microscopy, and vibrating sample magnetometry techniques. The toxicity was evaluated using variations in cell viability, cell morphology, protein degradation, and oxidative stress. Ni/NiFeO-GO nanocomposites likewise prompt oxidative stress proved by the age of reactive oxygen species (ROS) and exhaustion of antioxidant glutathione. This is the first report indicating that Ni/NiFeO-GO nanocomposite-initiated cell death in through ROS age and oxidative stress.
最近的研究表明,镍铁氧体纳米颗粒及其衍生物对细菌细胞具有毒性作用。在本研究中,我们制备了镍铁氧体纳米颗粒(Ni/NiFeO)和镍/镍铁氧体氧化石墨烯(Ni/NiFeO-GO)纳米复合材料,并评估了它们对ATCC 25922细胞的毒性作用。使用X射线衍射、拉曼光谱、扫描电子显微镜、透射电子显微镜和振动样品磁强计技术对制备的纳米材料进行了表征。通过细胞活力、细胞形态、蛋白质降解和氧化应激的变化来评估毒性。Ni/NiFeO-GO纳米复合材料同样会引发氧化应激,这通过活性氧(ROS)的产生和抗氧化剂谷胱甘肽的耗尽得到证明。这是第一份表明Ni/NiFeO-GO纳米复合材料通过ROS产生和氧化应激导致细胞死亡的报告。
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