Bandazhevskiĭ Iu I
Farmakol Toksikol. 1987 May-Jun;50(3):67-8.
Pyrogenal was administered intramuscularly to albino rats in different terms of pregnancy in a single dose of 1000-1250 MTD/kg, twice with a 24-hour interval in a dose of 500-625 MTD/kg and repeatedly on 3rd-18th days of pregnancy in doses of 1.0-1.2, 5.0-6.3, 50.0-63.0 MTD/kg. Fetuses were studied on 20th day of pregnancy. Pyrogenal produced in embryos depending on the time of administration and dose congenital developmental defects, a decrease of body weight, thrombohemorrhagic syndrome, and erythrocytic hemolysis.
将致热原以1000 - 1250最小中毒量/千克的单剂量，对处于不同孕期的白化大鼠进行肌肉注射；以500 - 625最小中毒量/千克的剂量，间隔24小时注射两次；并在妊娠第3至18天，分别以1.0 - 1.2、5.0 - 6.3、50.0 - 63.0最小中毒量/千克的剂量反复注射。在妊娠第20天对胎儿进行研究。根据给药时间和剂量的不同，致热原可导致胚胎出现先天性发育缺陷、体重减轻、血栓出血综合征以及红细胞溶血。
