[Effect of the bacterial polysaccharide pyrogenal on embryogenesis in noninbred white rats].

Pyrogenal was administered intramuscularly to albino rats in different terms of pregnancy in a single dose of 1000-1250 MTD/kg, twice with a 24-hour interval in a dose of 500-625 MTD/kg and repeatedly on 3rd-18th days of pregnancy in doses of 1.0-1.2, 5.0-6.3, 50.0-63.0 MTD/kg. Fetuses were studied on 20th day of pregnancy. Pyrogenal produced in embryos depending on the time of administration and dose congenital developmental defects, a decrease of body weight, thrombohemorrhagic syndrome, and erythrocytic hemolysis.