Bandazhevskiĭ Iu I, Nogteva G M, Lis R E, Miron A V
Arkh Anat Gistol Embriol. 1986 Apr;90(4):63-5.
Pyrogenal is injected to female hamsters (Mesocricetus auratus) at various time of pregnancy twice, with a 24 hour's interval: at first 100 or 50, and then--50 or 25 minimal pyrogenic doses. The embryos are examined on the 15th day of the intrauterine development by means of main teratologic methods. Pyrogenal injected on the 9th--10th day of the embryonal development produces hydrocephaly, micrognathia, retardation in development, hemorrhagic syndrome. Pyrogenal injected during some other time of pregnancy produces hemolysis of erythrocytes. This is proved by presence of hemosiderin in the foetal liver.
在怀孕的不同时间给雌性仓鼠（金黄地鼠）注射两次热原质，间隔24小时：第一次注射100或50个最小致热剂量，然后第二次注射50或25个最小致热剂量。通过主要的致畸学方法在子宫内发育的第15天检查胚胎。在胚胎发育的第9至10天注射热原质会导致脑积水、小颌畸形、发育迟缓、出血综合征。在怀孕的其他一些时间注射热原质会导致红细胞溶血。这可通过胎儿肝脏中存在含铁血黄素得到证实。
