Zhang Qiang, Ma Xiaoming, Zhi Sanjun, Zhang Wei
School of Chemistry and Life Sciences, Suzhou University of Science and Technology, 99 Xuefu Road, Suzhou 215009, China.
School of Pharmacy, Changzhou University, 1 Gehu Road, Changzhou 213164, China.
Molecules. 2024 Jul 31;29(15):3620. doi: 10.3390/molecules29153620.
Synthetic radicals have intrinsic power for cascading and multifunctional reactions to construct diverse molecular scaffolds. In the previous review series, we covered 1,2-difunctionalizations, remote 1,3-, 1,4-, 1,5-, 1,6-, and 1,7-difunctionalizations, addition followed by cyclization reactions, and cycloaddition-initiated difunctionalizations. Presented in this paper are radical addition-initiated trifunctionalization reactions of alkenes, alkynes, and their derivatives. After the initial radical addition, there are different pathways, such as group or hydrogen atom transfer, cyclization, and radical coupling, to complete the second and third functionalizations.
合成自由基具有用于级联和多功能反应以构建多样分子骨架的内在能力。在之前的综述系列中，我们涵盖了1,2-双官能化、远程1,3-、1,4-、1,5-、1,6-和1,7-双官能化、加成随后环化反应以及环加成引发的双官能化。本文介绍的是烯烃、炔烃及其衍生物的自由基加成引发的三官能化反应。在最初的自由基加成之后，存在不同的途径，如基团或氢原子转移、环化和自由基偶联，以完成第二次和第三次官能化。
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