Mangold H K, Muramatsu T, Roughley B S, Weber N
FEBS Lett. 1987 Aug 10;220(1):220-2. doi: 10.1016/0014-5793(87)80908-0.
1-O-Alkyl-2,3-diacyl-sn-glycerols, the major constituents of ratfish (Chimaera monstrosa) liver oil, serve as starting material for the preparation of 1-O-alkyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholines, and 1-O-alkyl-2-O-methyl-sn-glycero-3-beta-D-glucopyranosides. Catalytic tritiation of the unsaturated alkyl moieties in these biologically active ether lipids affords the corresponding 3H-labeled substances.
1-O-烷基-2,3-二酰基-sn-甘油是银鲛（Chimaera monstrosa）肝油的主要成分，可作为制备1-O-烷基-sn-甘油-3-磷酸胆碱、1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱、1-O-烷基-2-O-甲基-sn-甘油-3-磷酸胆碱和1-O-烷基-2-O-甲基-sn-甘油-3-β-D-吡喃葡萄糖苷的起始原料。这些生物活性醚脂中不饱和烷基部分的催化氚化可得到相应的3H标记物质。
