Aloysius Mark M, Shrivastava Sanskriti, Rojulpote Chaitanya, Naseer Raza, Hanif Hamza, Babic Milos, Gentilezza Kenneth, Boruah Pranjal K, Pancholy Samir
Department of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, United States.
Department of Physical Medicine and Rehabilitation, The Wright Center for Graduate Medical Education, Scranton, PA, United States.
Front Cardiovasc Med. 2022 Aug 25;9:961160. doi: 10.3389/fcvm.2022.961160. eCollection 2022.
There is limited insight into the epidemiological characteristics and effect of race and ethnicity on Primary Malignant Cardiac Tumors (PMCTs).
Comparison of clinical characteristics and cancer-specific survival outcomes of major races in the United States from the Surveillance, Epidemiology and End-Result (SEER) registry.
ICD-O-3 codes were used to identify PMCTs for the years 1975 to 2015. Three major races were identified-"White", "Black", and "Asian/Pacific Islander". Cancer-specific survival outcomes were compared using Kaplan-Meier analysis across and amongst races, based on tumor histology. A subgroup analysis of cancer-specific survival was performed between "Hispanics" and "non-Hispanics."
Seven hundred and twenty patients were identified-47% females and 79% White, mean age at diagnosis (47 ± 20 years). Black patients were significantly younger (39 ± 18 years) and presented more commonly with angiosarcomas (53%). Non-angiogenic sarcomas and lymphomas were the most common tumors in the White (38%) and Asian/Pacific Islander (34%) cohorts. For a median follow-up period of 50 (IQR3-86) months, cancer-specific survival (mean ± SD, in months) was worse in Blacks (9 ± 3) as compared to Whites (15 ± 1) and Asian/Pacific Islander (14 ± 1) (value; Black vs. White <0.001; Black vs. Asian/Pacific Islanders = 0.017, White vs. Asian/Pacific Islanders = 0.3). Subgroup analysis with 116 (16%) Hispanics (40% females; mean age of 40 ± 20 years) showed a longer mean cancer-specific survival of 16.9 ± 2.4 months as compared to 13.6 ± 1.1 months in non-Hispanics ( = 0.011).
Black and non-Hispanic patients have poorer cancer-specific survival in PMCTs.
关于原发性恶性心脏肿瘤（PMCTs）的流行病学特征以及种族和民族对其的影响，目前了解有限。
通过监测、流行病学和最终结果（SEER）登记处比较美国主要种族的临床特征和癌症特异性生存结果。
使用国际疾病分类肿瘤学第三版（ICD - O - 3）编码识别1975年至2015年的PMCTs。确定了三个主要种族——“白人”、“黑人”和“亚裔/太平洋岛民”。基于肿瘤组织学，使用Kaplan - Meier分析比较不同种族之间以及种族内部的癌症特异性生存结果。对“西班牙裔”和“非西班牙裔”进行了癌症特异性生存的亚组分析。
共识别出720例患者，其中47%为女性，79%为白人，诊断时的平均年龄为（47±20岁）。黑人患者明显更年轻（39±18岁），血管肉瘤的发生率更高（53%）。非血管肉瘤和淋巴瘤是白人（38%）和亚裔/太平洋岛民（34%）队列中最常见的肿瘤。中位随访期为50（四分位间距3 - 86）个月，黑人的癌症特异性生存（平均±标准差，单位：月）为（9±3），低于白人（15±1）和亚裔/太平洋岛民（14±1）（数值；黑人与白人比较<0.001；黑人与亚裔/太平洋岛民比较 = 0.017，白人与亚裔/太平洋岛民比较 = 0.3）。对116名（16%）西班牙裔患者（40%为女性；平均年龄40±20岁）进行的亚组分析显示，其癌症特异性生存平均时间为16.9±2.4个月，长于非西班牙裔患者的13.6±1.1个月（P = 0.011）。
黑人及非西班牙裔患者在PMCTs中的癌症特异性生存情况较差。
