Webley G E, Lenton E A
Fertil Steril. 1987 Aug;48(2):218-22. doi: 10.1016/s0015-0282(16)59345-5.
The relationship between the concentrations of melatonin and prolactin (PRL) over 24 hours has been investigated. Two peaks in PRL concentrations were distinguished: an evening peak (at 8:00 P.M.) and a nocturnal peak (at 6:00 A.M.). Melatonin concentrations showed a single peak (at 2:00 A.M.). In both the follicular and luteal phases of the menstrual cycle, melatonin increased 2 to 3 hours after the evening increase in PRL and 4 hours before the nocturnal rise in PRL concentrations. Oral administration of melatonin stimulated PRL release. The PRL response varied with menstrual cycle stage being significantly greater in the ovulatory (P less than 0.001) and luteal (P less than 0.01) phases than in the follicular phase. The results suggest that melatonin may be involved in control of the nocturnal PRL increase.
对褪黑素和催乳素（PRL）在24小时内的浓度关系进行了研究。PRL浓度出现两个峰值：一个傍晚峰值（晚上8点）和一个夜间峰值（早上6点）。褪黑素浓度呈现一个单一峰值（凌晨2点）。在月经周期的卵泡期和黄体期，褪黑素在傍晚PRL升高后2至3小时增加，在夜间PRL浓度升高前4小时增加。口服褪黑素刺激PRL释放。PRL反应随月经周期阶段而变化，在排卵期（P<0.001）和黄体期（P<0.01）比卵泡期显著更大。结果表明，褪黑素可能参与夜间PRL升高的调控。
