Donnez J, Lemaire-Rubbers M, Karaman Y, Nisolle-Pochet M, Casanas-Roux F
Fertil Steril. 1987 Aug;48(2):239-42. doi: 10.1016/s0015-0282(16)59349-2.
Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. A significant regression of the ovarian and peritoneal implants was observed in 72% of the cases after progestative treatment, but the presence of residual epithelium in all cases made surgical resection necessary. After preoperative medical treatment and microsurgery, intrauterine (living births) pregnancy rates of 60 and 47% were obtained in cases of moderate and severe endometriosis, respectively. The following prognostic factors were found in this series: the degree of endometriosis, the concomitant male factors, the decrease of endometriotic lesions after treatment, and the unilaterality of ovarian endometriosis.
五十例中度或重度子宫内膜异位症患者在进行显微手术前，接受了每日5毫克炔雌醇甲醚治疗，为期6个月。孕激素治疗后，72%的病例中观察到卵巢和腹膜植入物有显著消退，但所有病例中均存在残留上皮，因此仍需进行手术切除。术前药物治疗和显微手术后，中度和重度子宫内膜异位症患者的宫内（活产）妊娠率分别为60%和47%。本系列研究发现了以下预后因素：子宫内膜异位症的程度、伴发的男性因素、治疗后子宫内膜异位病变的减少以及卵巢子宫内膜异位症的单侧性。
