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复发多发性骨髓瘤的皮肤受累情况。

Cutaneous involvement in relapsed multiple myeloma.

作者信息

Salle Valéry, Attencourt Christophe, Chevalier Marion, Semeria Lucile, Boulu Xavier, Karam Jean-Denis, Smail Amar, Schmidt Jean, Duhaut Pierre, Dernoncourt Amandine

机构信息

Department of Internal Medicine Amiens University Hospital Amiens France.

Department of Pathology Amiens University Hospital Amiens France.

出版信息

Clin Case Rep. 2022 Sep 5;10(9):e6282. doi: 10.1002/ccr3.6282. eCollection 2022 Sep.

DOI:10.1002/ccr3.6282
PMID:36093446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9445254/
Abstract

Cutaneous involvement in multiple myeloma with extramedullary disease is rare. We report the case of a refractory multiple myeloma patient who developed a cutaneous lesion. Histopathology revealed dermal immature plasma cell infiltrate with a lack of CD138 expression. This cutaneous location was associated with an aggressive clinical course and short survival.

摘要

多发性骨髓瘤伴髓外病变累及皮肤的情况罕见。我们报告了一例难治性多发性骨髓瘤患者出现皮肤病变的病例。组织病理学显示真皮内有未成熟浆细胞浸润，且缺乏CD138表达。这种皮肤病变与侵袭性临床病程及较短生存期相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/5a9a9a9b0510/CCR3-10-e6282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/4cff98fbde44/CCR3-10-e6282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/989b2ff27aad/CCR3-10-e6282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/5a9a9a9b0510/CCR3-10-e6282-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/4cff98fbde44/CCR3-10-e6282-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/989b2ff27aad/CCR3-10-e6282-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/9445254/5a9a9a9b0510/CCR3-10-e6282-g003.jpg

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本文引用的文献

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Cutaneous localization of plasmablastic multiple myeloma with heterotopic expression of CD3 and CD4: Skin involvement revealing systemic disease.伴有CD3和CD4异位表达的浆母细胞性多发性骨髓瘤的皮肤定位：皮肤受累揭示全身性疾病。
J Cutan Pathol. 2019 Aug;46(8):619-622. doi: 10.1111/cup.13486. Epub 2019 May 10.
2
Extramedullary disease in multiple myeloma - controversies and future directions.多发性骨髓瘤中的髓外疾病——争议与未来方向。
Blood Rev. 2019 Jul;36:32-39. doi: 10.1016/j.blre.2019.04.002. Epub 2019 Apr 13.
3
Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?
在基于硼替佐米的治疗背景下多发性骨髓瘤的皮肤定位：骨髓瘤细胞如何从骨髓逃逸至皮肤？
Int J Hematol. 2017 Jan;105(1):104-108. doi: 10.1007/s12185-016-2104-1. Epub 2016 Oct 3.
4
Comparison of intramedullary myeloma and corresponding extramedullary soft tissue plasmacytomas using genetic mutational panel analyses.使用基因突变组分析对髓内骨髓瘤和相应的髓外软组织浆细胞瘤进行比较。
Blood Cancer J. 2016 May 20;6(5):e426. doi: 10.1038/bcj.2016.35.
5
Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation.多发性骨髓瘤（MM）皮肤累及：病例系列及临床病理相关性研究。
J Am Acad Dermatol. 2016 May;74(5):878-84. doi: 10.1016/j.jaad.2015.12.028. Epub 2016 Feb 11.
6
Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases.多发性骨髓瘤髓外疾病的特征：p53缺失频率高及生存率低：一项对834例病例的回顾性单中心研究
Clin Lymphoma Myeloma Leuk. 2015 May;15(5):286-91. doi: 10.1016/j.clml.2014.12.013. Epub 2015 Jan 3.
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Ann Oncol. 2010 Feb;21(2):325-330. doi: 10.1093/annonc/mdp329. Epub 2009 Jul 24.
8
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Multiple myeloma with skin involvement.
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10
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Mod Pathol. 2001 Oct;14(10):1052-8. doi: 10.1038/modpathol.3880435.