Steno Diabetes Center Copenhagen, Herlev, Denmark.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Diabetes Care. 2022 Nov 1;45(11):2746-2748. doi: 10.2337/dc22-0852.
We investigated endotrophin, a profibrotic signaling molecule reflecting collagen VI formation, in serum and urine as risk marker for complications to type 2 diabetes.
Endotrophin was measured in 774 individuals with type 2 diabetes. Outcomes included a composite kidney end point, first major adverse cardiovascular event (MACE), mortality, progression of albuminuria, incident heart failure, and sight-threatening eye disease. Adjusted Cox proportional hazards models were applied.
Doubling of serum endotrophin was associated with the kidney end point (n = 49; hazard ratio 1.80 [95% CI 1.13-2.87]), first MACE (n = 66; 1.54 [1.04-2.28]), mortality (n = 156; 1.69 (1.31-2.19]), and incident heart failure (n = 42; 1.63 [1.02-2.60]). A doubling of urine endotrophin was associated with progression of albuminuria (n = 85; 1.20 [1.04-1.39]).
Serum endotrophin was a risk marker for mortality and kidney and cardiovascular complications in type 2 diabetes. Urine endotrophin was a marker for albuminuria progression.
我们研究了内抑素，一种反映胶原 VI 形成的促纤维化信号分子，作为 2 型糖尿病并发症的风险标志物。
我们测量了 774 名 2 型糖尿病患者的内抑素水平。研究结果包括复合肾脏终点、首次主要不良心血管事件（MACE）、死亡率、白蛋白尿进展、心力衰竭事件和威胁视力的眼病。采用校正的 Cox 比例风险模型进行分析。
血清内抑素水平加倍与肾脏终点（n = 49；风险比 1.80 [95% CI 1.13-2.87]）、首次 MACE（n = 66；1.54 [1.04-2.28]）、死亡率（n = 156；1.69 [1.31-2.19]）和心力衰竭事件（n = 42；1.63 [1.02-2.60]）相关。尿液内抑素水平加倍与白蛋白尿进展相关（n = 85；1.20 [1.04-1.39]）。
血清内抑素是 2 型糖尿病患者死亡和肾脏及心血管并发症的风险标志物。尿液内抑素是白蛋白尿进展的标志物。
