Zachariae H, Thestrup-Pedersen K
Dermatologica. 1987;175(1):29-32. doi: 10.1159/000248778.
A case is presented of a 58-year-old female exhibiting a severe pustular psoriasis of the acrodermatitis continua type treated with ciclosporin A. The disease which had lasted for 10 years and had lead to 14 hospitalizations had previously been treated with methotrexate, systemic steroids, etretinate, colchicine, hydroxyurea and PUVA, or combinations of some of these drugs without producing complete remissions. Ciclosporin A (14 mg/kg/day/reduced to 7.5 mg/kg/day) produced complete remission in three weeks. Whether the patient can be maintained on low-dose ciclosporin A without toxicity remains to be seen. The drug, however, seems to be effective in bringing the disease under control.
本文报告了一例58岁女性，患有连续性肢端皮炎型严重脓疱型银屑病，接受环孢素A治疗。该疾病已持续10年，导致患者住院14次，此前曾用甲氨蝶呤、全身用类固醇、阿维A、秋水仙碱、羟基脲和光化学疗法（PUVA）或其中一些药物的联合治疗，但均未完全缓解。环孢素A（14mg/kg/天，减至7.5mg/kg/天）在三周内使病情完全缓解。患者能否在无毒性的情况下维持低剂量环孢素A治疗还有待观察。然而，该药似乎能有效控制病情。
