Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
J Pharm Pharmacol. 2022 Nov 4;74(11):1568-1587. doi: 10.1093/jpp/rgac057.
This study aims to review and describe the ethnobotanical, phytochemical and biological activity of various extracts and compounds isolated from Lansium domesticum Corr. from 1967 to 2022 and to study the opportunities that can be developed in the future in the pharmaceutical and pharmacology fields. The related articles, followed by the classification of L. domesticum Corr. according to ethnobotanical, biological and phytochemical properties, were collected from SciFinder, Google Scholar and PubMed.
More than 80 compounds have been isolated and identified from L. domesticum Corr., including terpenoids and their glycosides. Furthermore, the pharmacological activity of the extracts and pure compounds of L. domesticum Corr. tested in vitro and in vivo were mainly confirmed to include antifeedant, antimalarial, antimicrobial, antibacterial, and radical scavenging activity, antimutagenic, and anticancer.
In conclusion, based on this review, all data on the phytochemical and biological activity of L. domesticum Corr. can be used to support scientists in further research aim to determine the reaction mechanism of the extracts or compounds and need to be further validated using in vivo models together with toxicological analysis to establish their maximum tolerated dose.
本研究旨在回顾和描述 1967 年至 2022 年期间从大蒲桃（Lansium domesticum Corr.）中分离得到的各种提取物和化合物的民族植物学、植物化学和生物活性，并研究未来在制药和药理学领域可能开发的机会。相关文章通过 SciFinder、Google Scholar 和 PubMed 收集，并根据民族植物学、生物和植物化学特性对大蒲桃进行了分类。
从大蒲桃 Corr. 中已分离鉴定出 80 多种化合物，包括萜类化合物及其糖苷。此外，体外和体内试验证实大蒲桃 Corr. 提取物和纯化合物的药理活性主要包括拒食、抗疟、抗菌、抗细菌和自由基清除活性、抗突变和抗癌活性。
总之，基于本综述，大蒲桃 Corr. 的植物化学和生物活性的所有数据都可用于支持科学家进一步研究，以确定提取物或化合物的反应机制，并需要与毒理学分析一起使用体内模型进一步验证，以确定其最大耐受剂量。
