Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.
Department of Population Health Sciences, Weill Cornell Medical College, New York City, NY.
Diabetes. 2022 Dec 1;71(12):2702-2706. doi: 10.2337/db22-0549.
This study examined the incidence trends of new-onset type 1 and type 2 diabetes in children and adolescents in Florida before and during the coronavirus disease 2019 (COVID-19) pandemic. In this observational descriptive cohort study, we used a validated computable phenotype to identify incident diabetes cases among individuals <18 years of age in the OneFlorida+ network of the national Patient-Centered Clinical Research Network between January 2017 and June 2021. We conducted an interrupted time series analysis based on the autoregressive integrated moving average model to compare changes in age-adjusted incidence rates of type 1 and type 2 diabetes before and after March 2020, when COVID-19 was declared a national health emergency in the U.S. The age-adjusted incidence rates of both type 1 and type 2 diabetes increased post-COVID-19 for children and adolescents. These results highlight the need for longitudinal cohort studies to examine how the pandemic might influence subsequent diabetes onset in young individuals.
本研究调查了 2019 年冠状病毒病(COVID-19)大流行前后佛罗里达州儿童和青少年新发 1 型和 2 型糖尿病的发病趋势。在这项观察性描述性队列研究中,我们使用经过验证的可计算表型在全国患者为中心的临床研究网络的 OneFlorida+ 网络中,在 2017 年 1 月至 2021 年 6 月期间,确定年龄<18 岁的个体中新发糖尿病病例。我们基于自回归综合移动平均模型进行了中断时间序列分析,以比较 COVID-19 在美国被宣布为国家卫生紧急事件前后,1 型和 2 型糖尿病的年龄调整发病率的变化。COVID-19 之后,儿童和青少年的 1 型和 2 型糖尿病的年龄调整发病率均增加。这些结果强调需要进行纵向队列研究,以研究大流行如何影响年轻人随后的糖尿病发病。