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SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany.美国科罗拉多州和德国巴伐利亚州儿童及青少年中的新冠病毒感染与症状前1型糖尿病自身免疫
JAMA. 2022 Sep 27;328(12):1252-1255. doi: 10.1001/jama.2022.14092.
2
Increase in newly diagnosed type 1 diabetes in youth during the COVID-19 pandemic in the United States: A multi-center analysis.美国 COVID-19 大流行期间青少年新发 1 型糖尿病的增加:一项多中心分析。
Pediatr Diabetes. 2022 Jun;23(4):433-438. doi: 10.1111/pedi.13328. Epub 2022 Mar 16.
3
Increase in the Number of Pediatric New-Onset Diabetes and Diabetic Ketoacidosis Cases During the COVID-19 Pandemic.新冠疫情期间儿童新发糖尿病和糖尿病酮症酸中毒病例数增加。
Endocr Pract. 2022 May;28(5):479-485. doi: 10.1016/j.eprac.2022.02.005. Epub 2022 Feb 18.
4
Incidence of New-Onset Type 1 Diabetes Among US Children During the COVID-19 Global Pandemic.新冠大流行期间美国儿童新发 1 型糖尿病的发病率。
JAMA Pediatr. 2022 Apr 1;176(4):414-415. doi: 10.1001/jamapediatrics.2021.5801.
5
Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry.德国 COVID-19 大流行期间儿童和青少年 1 型糖尿病的发病率:来自 DPV 登记处的结果。
Diabetes Care. 2022 Aug 1;45(8):1762-1771. doi: 10.2337/dc21-0969.
6
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia.GP73 是一种生糖激素,有助于 SARS-CoV-2 引起的高血糖。
Nat Metab. 2022 Jan;4(1):29-43. doi: 10.1038/s42255-021-00508-2. Epub 2022 Jan 6.
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Risks of and From SARS-CoV-2 Infection and COVID-19 in People With Diabetes: A Systematic Review of Reviews.糖尿病患者感染 SARS-CoV-2 病毒和 COVID-19 的风险:系统综述。
Diabetes Care. 2021 Dec;44(12):2790-2811. doi: 10.2337/dc21-0930. Epub 2021 Oct 28.
8
The OneFlorida Data Trust: a centralized, translational research data infrastructure of statewide scope.OneFlorida 数据信托:一个集中的、具有全州范围的转化研究数据基础设施。
J Am Med Inform Assoc. 2022 Mar 15;29(4):686-693. doi: 10.1093/jamia/ocab221.
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Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.急性新冠肺炎中的高血糖症表现为胰岛素抵抗以及严重急性呼吸综合征冠状病毒2对脂肪组织的感染性。
Cell Metab. 2021 Nov 2;33(11):2174-2188.e5. doi: 10.1016/j.cmet.2021.09.009. Epub 2021 Sep 16.
10
Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children.罗马尼亚儿童在 COVID-19 大流行期间 1 型糖尿病发病率上升。
Medicina (Kaunas). 2021 Sep 16;57(9):973. doi: 10.3390/medicina57090973.

新冠疫情前后佛罗里达州儿童和青少年新发糖尿病的发病趋势:研究结果

Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida.

机构信息

Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.

Department of Population Health Sciences, Weill Cornell Medical College, New York City, NY.

出版信息

Diabetes. 2022 Dec 1;71(12):2702-2706. doi: 10.2337/db22-0549.

DOI:10.2337/db22-0549
PMID:36094294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9750945/
Abstract

This study examined the incidence trends of new-onset type 1 and type 2 diabetes in children and adolescents in Florida before and during the coronavirus disease 2019 (COVID-19) pandemic. In this observational descriptive cohort study, we used a validated computable phenotype to identify incident diabetes cases among individuals <18 years of age in the OneFlorida+ network of the national Patient-Centered Clinical Research Network between January 2017 and June 2021. We conducted an interrupted time series analysis based on the autoregressive integrated moving average model to compare changes in age-adjusted incidence rates of type 1 and type 2 diabetes before and after March 2020, when COVID-19 was declared a national health emergency in the U.S. The age-adjusted incidence rates of both type 1 and type 2 diabetes increased post-COVID-19 for children and adolescents. These results highlight the need for longitudinal cohort studies to examine how the pandemic might influence subsequent diabetes onset in young individuals.

摘要

本研究调查了 2019 年冠状病毒病(COVID-19)大流行前后佛罗里达州儿童和青少年新发 1 型和 2 型糖尿病的发病趋势。在这项观察性描述性队列研究中,我们使用经过验证的可计算表型在全国患者为中心的临床研究网络的 OneFlorida+ 网络中,在 2017 年 1 月至 2021 年 6 月期间,确定年龄<18 岁的个体中新发糖尿病病例。我们基于自回归综合移动平均模型进行了中断时间序列分析,以比较 COVID-19 在美国被宣布为国家卫生紧急事件前后,1 型和 2 型糖尿病的年龄调整发病率的变化。COVID-19 之后,儿童和青少年的 1 型和 2 型糖尿病的年龄调整发病率均增加。这些结果强调需要进行纵向队列研究,以研究大流行如何影响年轻人随后的糖尿病发病。