Department of Cardiology, Faculty of Medicine Recep Tayyip Erdoğan University, Rize.
Department of Cardiology, Faculty of Medicine, Namik Kemal University, Tekirdağ, Turkey.
Blood Press Monit. 2022 Dec 1;27(6):384-390. doi: 10.1097/MBP.0000000000000618. Epub 2022 Sep 12.
Nondipper hypertensive patients have an increased incidence of damage to end organs, including the brain, heart, and kidney, and a worse cardiovascular prognosis. The triglyceride glucose (TyG) index is a reliable indicator of insulin resistance (IR) and is closely related to the traditional risk factors of cardiovascular disease. To the best of our knowledge, whether there is a relationship between the TyG index and impaired diurnal blood pressure (BP) has not been investigated. This study aimed to compare the TyG index between normotensive, nondipper, and dipper hypertensive patients. A total of 1037 patients grouped according to the results of ambulatory BP monitoring were included, with group 1 including dipper hypertensive ( n = 368), group 2 including nondipper hypertensive ( n = 496), and group 3 including normotensive control ( n = 173) patients. In both the univariate and multivariate logistic regression analyses, TyG index [odds ratio (OR), 4.656; 95% confidence interval (CI), 3.014-7.193; P < 0.001], age (OR, 1.011; 95% CI, 1.002-1.021; P = 0.018), and glomerular filtration rate (GFR) (OR, 0.979; 95% CI, 0.971-0.987; P < 0.001) were independent predictors of nondipper hypertension (HT). In the ROC analysis, a TyG index cutoff value of at least 4.74 predicted nondipper hypertensive patients with a sensitivity of 59.7%, and a specificity of 59.9% [area under the curve = 0.647 (0.614-0.680); 95% CI; P < 0.001]. We showed that TyG index, age, and GFR are independent predictors in patients with nondipper HT. TyG index, a simple, cost-effective, and rapid tool can predict the nondipper pattern in essential HT.
非杓型高血压患者终末器官损害的发生率增加，包括脑、心和肾，心血管预后更差。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗（IR）的可靠指标，与心血管疾病的传统危险因素密切相关。据我们所知，TyG 指数与日间血压（BP）受损之间是否存在关系尚未得到研究。本研究旨在比较正常血压、非杓型和杓型高血压患者的 TyG 指数。根据动态血压监测结果将 1037 例患者分为三组，第 1 组为杓型高血压（n=368），第 2 组为非杓型高血压（n=496），第 3 组为正常血压对照组（n=173）。在单因素和多因素 logistic 回归分析中，TyG 指数[比值比（OR），4.656；95%置信区间（CI），3.014-7.193；P<0.001]、年龄（OR，1.011；95%CI，1.002-1.021；P=0.018）和肾小球滤过率（GFR）（OR，0.979；95%CI，0.971-0.987；P<0.001）是非杓型高血压（HT）的独立预测因素。在 ROC 分析中，TyG 指数至少为 4.74 预测非杓型高血压患者的敏感性为 59.7%，特异性为 59.9%[曲线下面积=0.647（0.614-0.680）；95%CI；P<0.001]。我们表明，TyG 指数、年龄和 GFR 是非杓型 HT 患者的独立预测因素。TyG 指数是一种简单、经济有效的快速工具，可预测原发性 HT 中的非杓型模式。
