Hashimoto T, Onozaki K, Homma Y, Fukutomi Y, Ichikawa M
Dev Biol Stand. 1986;58 ( Pt B):553-9.
On the basis of present knowledge on the purification and the action mechanisms of macrophage regulating lymphokines, as summarized in Table VIII, tuberculosis immunity and tuberculin delayed type hypersensitivity may be dissociated at a level of responsible lymphokines. Table VIII. Dissociation of TB-IMM and DTH at a level of lymphokine 1. Purification of mediators resulted in separation of MIF/MAF and MCF 2. Anti-MIF antibody has no suppression of MCF reaction 3. Lipid metabolisms of macrophages stimulated with MIF/MAF and MCF are different 4. MIF/MAF suppresses MCF-reaction through monokines.
根据表八总结的关于巨噬细胞调节淋巴因子的纯化及其作用机制的现有知识，结核病免疫和结核菌素迟发型超敏反应可能在相关淋巴因子水平上分离。表八. 在淋巴因子水平上结核病免疫（TB-IMM）和迟发型超敏反应（DTH）的分离 1. 介质的纯化导致迁移抑制因子/巨噬细胞激活因子（MIF/MAF）和巨噬细胞趋化因子（MCF）的分离 2. 抗MIF抗体对MCF反应无抑制作用 3. 用MIF/MAF和MCF刺激的巨噬细胞的脂质代谢不同 4. MIF/MAF通过单核因子抑制MCF反应。
