卡介苗接种对典型和非典型结核菌素敏感性的定性影响。
Qualitative effect of BCG vaccination on sensitivity to typical and atypical tuberculins.
作者信息
Crispen R G
出版信息
Dev Biol Stand. 1986;58 ( Pt B):645-53.
Examination of medical student's and nursing student's sensitivity to PPD-Y, PPD-G and PPD-B before and after BCG vaccination revealed that some students who were not reactive prior to vaccination became strongly reactive to one or more of the atypical tuberculins after vaccination. This result is not due to BCG vaccine since it was not seen in guinea pigs or in children. This evidence of the interaction of multiple sensitivities after infections with different mycobacteria has significance in the interpretation of anti-tuberculosis immunity in BCG trials.
对医学生和护理学生在接种卡介苗前后对结核菌素纯蛋白衍生物-Y（PPD-Y）、结核菌素纯蛋白衍生物-G（PPD-G）和结核菌素纯蛋白衍生物-B（PPD-B）的敏感性进行检测，结果显示，一些在接种前无反应的学生在接种后对一种或多种非典型结核菌素产生了强烈反应。这一结果并非由卡介苗疫苗导致，因为在豚鼠或儿童中未观察到这种情况。这种不同分枝杆菌感染后多种敏感性相互作用的证据，在卡介苗试验中抗结核免疫的解释方面具有重要意义。
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