Sakai Ryoko, Tanaka Eiichi, Inoue Eisuke, Sato Minako, Tanaka Masaru, Ikari Katsunori, Yamanaka Hisashi, Harigai Masayoshi
Department of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Mod Rheumatol. 2023 Apr 13;33(3):496-502. doi: 10.1093/mr/roac053.
To explore patient-reported outcomes (PROs) related to quality of life (QOL) in patients with rheumatoid arthritis (RA) who achieved clinical remission.
In the Institute of Rheumatology, Rheumatoid Arthritis dataset, RA patients >18 years old who met the simplified disease activity index (SDAI) remission criteria in April 2017 were enrolled in this analysis. Pain-visual analogue scale (pain-VAS) (0-100 mm), patient's global assessment of disease activity (Pt-GA; 0-100 mm), Japanese version of the Health Assessment Questionnaire, duration of morning joint stiffness, and fatigue [Checklist Individual Strength 8R (CIS)] were the tools used to evaluate PROs. To assess the contribution of each PRO to the European QOL-5 Dimensions-5 Level (EQ-5D-5L) score, an analysis of variance was conducted.
Among the 2443 patients with remission, the mean EQ-5D-5L was 0.9. The mean pain-VAS and Pt-GA were 7.2 and 7.4, respectively. Factors that significantly contributed to the EQ-5D-5L were pain-VAS (48.8%), CIS score (18.1%), and Pt-GA (15.6%). Around 82.5% of the variance in EQ-5D-5L was explained by the three PROs.
This study demonstrated that pain-VAS, CIS, and Pt-GA were significant contributors to the EQ-5D-5L score in patients with RA who achieved the simplified disease activity index remission criteria.
探讨达到临床缓解的类风湿关节炎（RA）患者中与生活质量（QOL）相关的患者报告结局（PROs）。
在风湿病研究所的类风湿关节炎数据集中，纳入了2017年4月符合简化疾病活动指数（SDAI）缓解标准的18岁以上RA患者进行本分析。疼痛视觉模拟量表（疼痛-VAS）（0-100mm）、患者对疾病活动的整体评估（Pt-GA；0-100mm）、日本版健康评估问卷、晨僵持续时间和疲劳[个人力量清单8R（CIS）]是用于评估PROs的工具。为了评估每个PRO对欧洲生活质量五维度五级（EQ-5D-5L）评分的贡献，进行了方差分析。
在2443例缓解患者中，EQ-5D-5L的平均值为0.9。疼痛-VAS和Pt-GA的平均值分别为7.2和7.4。对EQ-5D-5L有显著贡献的因素是疼痛-VAS（48.8%）、CIS评分（18.1%）和Pt-GA（15.6%）。EQ-5D-5L约82.5%的方差可由这三个PROs解释。
本研究表明，对于达到简化疾病活动指数缓解标准的RA患者，疼痛-VAS、CIS和Pt-GA是EQ-5D-5L评分的重要贡献因素。
