聚多巴胺纳米粒子协同化疗-光热及铁死亡疗法治疗食管癌。
Synergistic chemo-photothermal and ferroptosis therapy of polydopamine nanoparticles for esophageal cancer.
机构信息
Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
出版信息
Nanomedicine (Lond). 2022 Jul;17(16):1115-1130. doi: 10.2217/nnm-2022-0064. Epub 2022 Sep 12.
To develop synergistic chemo-photothermal and ferroptosis therapy nanoparticles to improve the efficacy of treatment for esophageal cancer. FeO@PDA-HCPT nanoparticles (NPs) were constructed and characterized. Their synergistic antitumor effects were evaluated in EC1 and EC109 esophageal cancer cells as well as in esophageal cancer-bearing mice. and experiments showed that FeO@PDA-HCPT NPs exhibited significant tumor inhibition and excellent diagnostic properties. The killing ability of tumor cells was significantly enhanced after irradiation. Synergistic application of the three therapies effectively inhibited tumor growth and exhibited potent antitumor effects, providing strong support for developing nanoparticles with synergistic antitumor effects of multiple therapies.
为了开发协同的化疗-光热和铁死亡治疗纳米粒子，以提高食管癌治疗的效果。构建并表征了 FeO@PDA-HCPT 纳米粒子（NPs）。在 EC1 和 EC109 食管癌细胞以及食管癌荷瘤小鼠中评估了它们的协同抗肿瘤作用。实验表明，FeO@PDA-HCPT NPs 表现出显著的肿瘤抑制作用和优异的诊断性能。照射后肿瘤细胞的杀伤能力显著增强。三种疗法的协同应用有效地抑制了肿瘤生长，表现出强大的抗肿瘤作用，为开发具有多种疗法协同抗肿瘤作用的纳米粒子提供了有力支持。
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