N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of the Russian Federation.
Klin Lab Diagn. 2022 Aug 15;67(8):458-462. doi: 10.51620/0869-2084-2022-67-8-458-462.
The data of a comprehensive comparative study of the taxonomic composition of the resident microbiome of tumors from 26 patients with non-small cell lung cancer are presented. Analysis of taxonomic diversity revealed 10 types, 280 genera and 788 species of microorganisms. The analysis of the relative content and prognostic significance was carried out for 62 dominant genera. Differences in the relative abundance of bacteria of the genera Acinetobacter, Halomonas, and Chryseobacterium between tumor and conditionally normal lung tissue were found, but their diagnostic potential was not confirmed. The correlation analysis did not reveal any relationship between the content of various genera of bacteria and the histological type of the tumor, its localization, and the age of the patients. Differences were found in the content of the studied bacteria depending on the stage of the disease, the presence of regional metastases and tumor differentiation. The prognostic significance of bacteria of the genera Variovorax and Pseudoclavibacter in non-small cell lung cancer was established. The results obtained can be used in the development of new effective methods for the diagnosis and prognosis of non-small cell lung cancer.
本文呈现了对 26 名非小细胞肺癌患者肿瘤常驻微生物组分类组成的综合比较研究的数据。对分类多样性的分析揭示了 10 种、280 属和 788 种微生物。对 62 种主要属的相对含量和预后意义进行了分析。在肿瘤和条件正常肺组织之间发现了不动杆菌属、盐单胞菌属和黄杆菌属细菌相对丰度的差异，但它们的诊断潜力尚未得到证实。相关性分析未发现各种细菌属的含量与肿瘤的组织学类型、定位和患者年龄之间存在任何关系。根据疾病分期、区域性转移和肿瘤分化，研究细菌的含量存在差异。还确定了非小细胞肺癌中拟杆菌属和假单胞菌属细菌的预后意义。所获得的结果可用于开发非小细胞肺癌的新的有效诊断和预后方法。
