甘薯（Ipomoea batatas）对兔模型阿司匹林诱导胃溃疡的抗溃疡作用。

Antiulcerative potential of sweet potato (Ipomoea batatas) against aspirin-induced gastric ulcers in a rabbit model.

机构信息

National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture, Faisalabad, Pakistan.

出版信息

Nutrition. 2022 Nov-Dec;103-104:111799. doi: 10.1016/j.nut.2022.111799. Epub 2022 Jul 22.

DOI:10.1016/j.nut.2022.111799

PMID:36096055

Abstract

OBJECTIVES

Sweet potato (Ipomoea batatas) is accredited as a functional food because of its nutraceutical compounds. These dietary components may help heal lesions and ulcer scars in the stomach. This research was designed to examine the antioxidant and antiulcerative potential of sweet potato (red skin, white flesh) against aspirin-induced gastric ulcers in a rabbit model.

METHODS

Sweet potato samples were analyzed for in vitro analysis, such as 2,2-diphenyl-1-picrylhydrazyl assay, total phenolic content, and total flavonoid content. In a bioefficacy study, rabbits were divided into five groups (n = 6) in which G received the standard diet only, G 150 mg/kg aspirin, G 20 mg/kg omeprazole, G 1000 mg/kg aqueous extract of sweet potato, and G 1000 mg/kg ethanolic extract of sweet potato. After completion of the trial, the animals were decapitated and examined for antiulcer parameters, serum analysis, and hematologic parameters.

RESULTS

The mean values for 2,2-diphenyl-1-picrylhydrazyl, total phenolic content, and total flavonoid content were 57%, 927 mg gallic acid equivalent/100 g, and 1901 µg quercetin equivalent/g, respectively. The values for gastric volume, acid output, ulcer scores and index, total oxidant status, white blood cell count, and lymphocyte count were increased significantly (P < 0.05) for the positive control group compared with G, G, and G. Gastric pH and body weight at the end of the experiment were significantly reduced for the positive control group (P < 0.05) compared with G, G, and G. Histology test results of gastric tissues in G depicted severe epithelial damage compared with G, G, and G.

CONCLUSIONS

The results for the antiulcer parameters ascertained the antiulcer activity of sweet potato in aspirin-induced gastric ulcer models.

摘要

目的

由于含有营养成分，番薯（Ipomoea batatas）被认为是一种功能性食品。这些饮食成分可能有助于治愈胃部的损伤和溃疡疤痕。本研究旨在检验番薯（红皮白肉）的抗氧化和抗溃疡潜力，以了解其对兔模型中阿司匹林诱导的胃溃疡的影响。

方法

对番薯样本进行体外分析，如 2,2-二苯基-1-苦基肼（DPPH） assay、总酚含量和总黄酮含量分析。在生物功效研究中，将兔子分为五组（n=6），其中 G 组仅接受标准饮食，G150mg/kg 阿司匹林组、G20mg/kg 奥美拉唑组、G1000mg/kg 番薯水提物组和 G1000mg/kg 番薯醇提物组。试验结束后，对动物进行断头处理，检测抗溃疡参数、血清分析和血液学参数。

结果

DPPH、总酚含量和总黄酮含量的平均值分别为 57%、927mg 没食子酸当量/100g 和 1901µg 槲皮素当量/g。与 G 组、G 组和 G 组相比，阳性对照组的胃容积、胃酸分泌量、溃疡评分和指数、总氧化状态、白细胞计数和淋巴细胞计数显著增加（P<0.05）。与 G 组、G 组和 G 组相比，阳性对照组的胃 pH 值和实验结束时的体重显著降低（P<0.05）。与 G 组、G 组和 G 组相比，G 组的胃组织组织学检查结果显示严重的上皮损伤。