长期服用苄非他明的行为效应：神经化学意义

Behavioural effects of long-term administration of fencamfamine: neurochemical implications.

作者信息

Planeta C S, Scavone C, De Lucia R, Aizenstein M L

出版信息

Gen Pharmacol. 1987;18(4):347-9. doi: 10.1016/0306-3623(87)90089-9.

Abstract

The repeated effects of fencamfamine administration (10.0 mg/kg, i.p. single dose) were studied in male rats. Fencamfamine treatment increased stereotyped sniffing and decreased rearing behaviour. These changes occurred after 8 days of treatment and remained for 25 days. The fencamfamine repeated administration enhanced the homovanillic acid (HVA) level in the tubercullum olfactorium while the same treatment decreased the dihydroxyphenilacetic acid (DOPAC) and HVA striatal levels. The data suggest that long-term fencamfamine administration develops changes in the activity of parts of the DA systems which might be responsible for tolerance or sensitization to the effects of fencamfamine.

摘要

研究了在雄性大鼠中反复给予芬坎法明（10.0毫克/千克，腹腔注射单剂量）的效果。芬坎法明治疗增加了刻板嗅探行为并减少了竖毛行为。这些变化在治疗8天后出现，并持续了25天。反复给予芬坎法明提高了嗅结节中的高香草酸（HVA）水平，而相同处理降低了纹状体中二羟基苯乙酸（DOPAC）和HVA的水平。数据表明，长期给予芬坎法明会使多巴胺能系统部分区域的活性发生变化，这可能是对芬坎法明产生耐受性或敏感性的原因。