长期使用苄非他明对大鼠体重、食物摄入量及刻板行为的影响。
The effects of chronic treatment with fencamfamine on body weight, food intake and stereotyped behaviour in rats.
作者信息
DeLucia R, Aizenstein M L, Scavone C, Planeta C da S
出版信息
Gen Pharmacol. 1987;18(3):299-301. doi: 10.1016/0306-3623(87)90015-2.
The effects of chronic treatment with fencamfamine (10.0 mg/kg, i.p.) or saline were studied in rats. Chronic fencamfamine treatment reduced body weight of rats below their normal body weight. Thereafter, weight increased, in parallel to that of control rats. There was an increasing trend in food intake in both groups and a reduction was observed in food intake on the first seven days of fencamfamine-treated rats. Fencamfamine repeated administration enhanced stereotyped sniffing while rearing behaviour gradually declined until 25 days. However, the same treatment did not interfere with the intensity of stereotypy. These findings suggest the need for a re-evaluation of current concept in the tolerance to the effects of fencamfamine and other stimulant drugs.
研究了大鼠长期腹腔注射10.0毫克/千克芬坎法明或生理盐水的效果。长期给予芬坎法明会使大鼠体重低于正常体重。此后，体重开始增加，与对照大鼠平行。两组的食物摄入量均呈增加趋势，且在芬坎法明处理的大鼠的前七天观察到食物摄入量减少。重复给予芬坎法明会增强刻板嗅探行为，而立姿行为则逐渐下降，直至25天。然而，相同处理并未干扰刻板行为的强度。这些发现表明有必要重新评估当前对芬坎法明和其他兴奋剂药物耐受性的概念。
Zotero 插件