Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Dermatol Ther. 2022 Nov;35(11):e15819. doi: 10.1111/dth.15819. Epub 2022 Oct 3.
Brimonidine is a vasoconstrictive agent used to treat several dermatologic disorders. Here, we review the uses of brimonidine in different aspects of dermatology. We searched keywords including rosacea, erythema, topical brimonidine, dermatology, and skin disease in PubMed, Cochrane, and Google Scholar to collect the related published articles. In a review of 15 articles, we found topical brimonidine improved the facial erythema of rosacea. In addition, it reduced the erythema associated with alcohol flushing syndrome, intense pulsed light therapy, and photodynamic therapy. Furthermore, topical brimonidine was used as a hemostatic agent in dermatosurgery procedures such as Mohs surgery and nail surgery to reduce intra-operative and postoperative bleeding. Some side effects such as erythema, flushing, and burning were reported in a few patients. Based on our findings, brimonidine is a beneficial drug that can be used in various dermatologic disorders with negligible side effects.
溴莫尼定是一种血管收缩剂，用于治疗多种皮肤科疾病。在这里，我们综述了溴莫尼定在皮肤科不同方面的应用。我们在 PubMed、Cochrane 和 Google Scholar 中使用包括酒渣鼻、红斑、局部溴莫尼定、皮肤病和皮肤疾病在内的关键词搜索相关已发表文章。在对 15 篇文章的综述中，我们发现局部溴莫尼定可改善酒渣鼻的面部红斑。此外，它还可减轻酒精性潮红综合征、强脉冲光治疗和光动力治疗相关的红斑。此外，局部溴莫尼定可作为Mohs 手术和指甲手术等皮肤外科手术中的止血剂，以减少术中及术后出血。少数患者报告有一些副作用，如红斑、潮红和灼热感。基于我们的研究结果，溴莫尼定是一种有益的药物，可用于多种皮肤科疾病，副作用极小。
