Department of Cataract, Shanxi Eye Hospital, Taiyuan 030002.
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Aug 28;47(8):1075-1081. doi: 10.11817/j.issn.1672-7347.2022.210780.
Central serous chorioretinopathy (CSC) is generally a common fundus disease in young and middle-aged Asian men. Acute and chronic CSC can lead to different degrees of injury to the retinal blood flow. This study aims to observe and compare the blood flow density in different retinal capillary layers in patients with acute and chronic CSC using optical coherence tomography angiography (OCTA) technology.
Twelve patients with acute CSC and 8 patients with chronic CSC including 12 eyes with acute CSC (acute CSC eye group), 11 eyes with chronic CSC (chronic CSC eye group), and 17 normal eyes (normal eye group) were enrolled in this study. All patients underwent 3 mm×3 mm, 6 mm×6 mm macular OCTA scanning. The retinal microvascu-lature was divided into superficial vascular complexes (SVC), intermediate capillary plexuses (ICP), and deep capillary plexuses (DCP) using the projection resolved-OCTA algorithm. Inner retina includes SVC, ICP, and DCP. The vessel density in each retinal layer and the inner retina were calculated and compared.
Macular OCTA scanning of 3 mm×3 mm showed that there was no significant difference in blood flow density of SVC and ICP among the 3 groups (both >0.05); blood flow density of DCP and inner retina in the chronic CSC eye group was significantly lower than that in the acute CSC eye group and the normal eye group (all <0.05); there was no significant difference in retinal blood flow density of different layer between the acute CSC eye group and the normal eye group (all >0.05). Macular OCTA scanning of 6 mm×6 mm showed that inner retinal blood flow density of the chronic CSC eye group was significantly lower than that of the acute CSC eye group and the normal eye group (both <0.05); there was no significant difference in blood flow density of SVC among the 3 groups (>0.05).
The vessel density of DCP and inner retina in the eyes with chronic CSC are significantly reduced, which may result in impaired visual function. Therefore, we recommend that patients with acute CSC should be properly treated to avoid progressing into chronic CSC.
中心性浆液性脉络膜视网膜病变（CSC）通常是亚洲中青年男性常见的眼底疾病。急性和慢性 CSC 可导致视网膜血流不同程度的损伤。本研究旨在利用光相干断层扫描血管造影（OCTA）技术观察和比较急性和慢性 CSC 患者不同视网膜毛细血管层的血流密度。
纳入 12 例急性 CSC 患者和 8 例慢性 CSC 患者，共 12 只眼为急性 CSC（急性 CSC 眼组），11 只眼为慢性 CSC（慢性 CSC 眼组），17 只眼为正常眼（正常眼组）。所有患者均行 3mm×3mm、6mm×6mm 黄斑 OCTA 扫描。采用投影分辨 OCTA 算法将视网膜微血管分为浅层血管复合体（SVC）、中间毛细血管丛（ICP）和深层毛细血管丛（DCP）。内层视网膜包括 SVC、ICP 和 DCP。计算并比较各视网膜层和内层的血管密度。
3mm×3mm 黄斑 OCTA 扫描显示，3 组间 SVC 和 ICP 的血流密度差异无统计学意义（均>0.05）；慢性 CSC 眼组 DCP 和内层视网膜的血流密度明显低于急性 CSC 眼组和正常眼组（均<0.05）；急性 CSC 眼组与正常眼组各层视网膜血流密度差异无统计学意义（均>0.05）。6mm×6mm 黄斑 OCTA 扫描显示，慢性 CSC 眼组内层视网膜血流密度明显低于急性 CSC 眼组和正常眼组（均<0.05）；3 组间 SVC 血流密度差异无统计学意义（>0.05）。
慢性 CSC 患者的 DCP 和内层视网膜血管密度明显降低，可能导致视力功能受损。因此，我们建议急性 CSC 患者应进行适当治疗，避免进展为慢性 CSC。
