Department of Neurology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Department of General Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Turk J Gastroenterol. 2022 Dec;33(12):1050-1057. doi: 10.5152/tjg.2022.22086.
Pancreatic duct stones obstruct the pancreatic ducts and aggravate clinical symptoms of chronic pancreatitis. Only isolated case reports have shown that some drugs may be useful in dissolving pancreatic duct stones. Endothelium corneum gigeriae galli is a Chinese medicine widely used to cure multifarious lithiasis and maldigestion. This study aimed to evaluate the efficacy of endothelium corneum gigeriae galli oral therapy in the dissolution of stones and evaluate the improvement of clinical symptoms in patients with pancreatic duct stones.
Sixty-eight patients with pancreatic duct stones were randomly divided into the endothelium corneum gigeriae galli and control groups. Endothelium corneum gigeriae galli was given orally to the endothelium corneum gigeriae galli group, and the placebo was given to the control group. Both groups were reviewed by computed tomography and magnetic resonance imaging; abdominal pain, exocrine and endocrine pancreatic function, and the nutritional status of patients were measured after the study.
The dissolution rate of the endothelium corneum gigeriae galli group was significantly higher than that of the control group (P = .002). The abdominal pain of the endothelium corneum gigeriae galli group was relieved more significantly compared to that of the control group (P < .001). The exocrine and endocrine pancreatic function of the endothelium corneum gigeriae galli group improved more significantly than that of the control group (P < .001). The nutritional status of the endothelium corneum gigeriae galli group was significantly higher than that of the control group (P = .003).
Overall, oral endothelium corneum gigeriae galli treatment could dissolve pancreatic duct stones, relieve abdominal pain, improve exocrine and endocrine pancreatic functions, and control the deterioration of nutritional status. Endothelium corneum gigeriae galli treatment should be useful in pancreatic duct stones therapy.
胰管结石会阻塞胰管，加重慢性胰腺炎的临床症状。仅有孤立的病例报告表明，某些药物可能有助于溶解胰管结石。鸡内金是一种中药，广泛用于治疗多种结石和消化不良。本研究旨在评估鸡内金口服疗法在溶解结石方面的疗效，并评估其对胰管结石患者临床症状改善的作用。
将 68 例胰管结石患者随机分为鸡内金组和对照组。鸡内金组给予鸡内金口服治疗，对照组给予安慰剂。两组均通过计算机断层扫描和磁共振成像进行复查；研究结束后，测量患者的腹痛、外分泌和内分泌胰腺功能以及营养状况。
鸡内金组的溶解率明显高于对照组（P =.002）。鸡内金组的腹痛缓解程度明显高于对照组（P <.001）。鸡内金组的外分泌和内分泌胰腺功能改善程度明显高于对照组（P <.001）。鸡内金组的营养状况明显优于对照组（P =.003）。
总体而言，鸡内金口服治疗可溶解胰管结石，缓解腹痛，改善外分泌和内分泌胰腺功能，并控制营养状况恶化。鸡内金治疗可能对胰管结石治疗有用。
