钯催化2-烯丙基芳基三氟甲磺酸酯的全氟烷基化羰基化反应：碱控制下选择性合成β-全氟烷基酰胺
Palladium-Catalyzed Perfluoroalkylative Carbonylation of 2-Allylaryl Trifluoromethanesulfonates: Base-Controlled Selective Access to β-Perfluoroalkyl Amides.
作者信息
Zhang Youcan, Bao Zhi-Peng, Xu Jian-Xing, Wu Xiao-Feng
机构信息
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.
Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
出版信息
Org Lett. 2022 Sep 23;24(37):6845-6850. doi: 10.1021/acs.orglett.2c02779. Epub 2022 Sep 13.
A palladium-catalyzed perfluoroalkylative carbonylation of 2-allylaryl trifluoromethanesulfonates has been developed. A range of 2-allyl trifluoromethanesulfonates, perfluoroalkyl halides, and amines were applied in this tandem procedure to provide the corresponding β-perfluoroalkyl amides with good functional group tolerance and high chemoselectivity. The final products were controlled by the base applied.
已开发出一种钯催化的2-烯丙基芳基三氟甲磺酸酯的全氟烷基化羰基化反应。一系列2-烯丙基三氟甲磺酸酯、全氟烷基卤化物和胺被应用于该串联反应中，以提供具有良好官能团耐受性和高化学选择性的相应β-全氟烷基酰胺。最终产物由所使用的碱控制。
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