Adams J E
Appl Neurophysiol. 1977;40(2-4):111-23. doi: 10.1159/000102437.
The effectiveness of implantation of depth electrodes for pain control in (a) the primary thalamic relay nuclei, and (b) the periventricular gray matter or periaqueductal gray matter is reviewed. In a series of 39 patients, 14 achieved relief with no further need for medication, 16 were able to reduce their drug intake and 9 experienced no relief. These results are compared to those for a series of 76 patients reported on by an international study group of neurological surgeons. 61 patients in this series were considered to have had a successful result immediately after implantation of the electrode, but at the time of follow-up only 42 were still in this category. The implantation of depth electrodes requires a technique that fulfills the following criteria: (1) the procedure must be performed in a fully awake, cooperative patient; (2) a precise stereotactic technique must be employed, and (3) the effects of stimulation must be evaluated before the implant is made permanent. The most common complication was infection at the implantation site; this can be reduced by the use of Teflon-insulated percutaneous leads. Other complications include erosion of the hardware through the scalp and internal migration of the electrodes.
本文综述了在(a)丘脑主要中继核,以及(b)脑室周围灰质或导水管周围灰质植入深度电极用于疼痛控制的有效性。在一组39例患者中,14例疼痛缓解且无需进一步药物治疗,16例能够减少药物摄入量,9例未获缓解。这些结果与一个国际神经外科医生研究小组报告的一组76例患者的结果进行了比较。该组中的61例患者在电极植入后立即被认为手术成功,但在随访时,只有42例仍属此类。深度电极植入需要一种满足以下标准的技术:(1)手术必须在完全清醒、配合的患者身上进行;(2)必须采用精确的立体定向技术;(3)在植入物永久化之前必须评估刺激效果。最常见的并发症是植入部位感染;使用聚四氟乙烯绝缘的经皮导线可减少这种情况。其他并发症包括硬件穿出头皮以及电极向内部移位。