真菌中天然存在的部分还原的苯并菲醌。

Naturally Occurring Partially Reduced Perylenequinones from Fungi.

机构信息

Laboratório de Biotecnologia e Química de Microrganismos (LBQM), Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Rua Barão de Jeremoabo S/n, 40170-115 Salvador, Brasil.

School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.

出版信息

J Nat Prod. 2022 Sep 23;85(9):2236-2250. doi: 10.1021/acs.jnatprod.2c00368. Epub 2022 Sep 13.

DOI:10.1021/acs.jnatprod.2c00368

PMID:36098709

Abstract

This Review provides a critical analysis of the literature covering the naturally occurring partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can be named class A perylenequinones) and discusses their structures, stereochemistry, biosynthesis, and biological activities as appropriate. Perylenequinones are natural pigments with a perylene skeleton produced by certain fungi, aphids, some plants, and animal species. These compounds display several biological activities, e.g., antimicrobial, anti-HIV, photosensitizers, cytotoxic, and phytotoxic. It describes 36 fungal PQs and cites 81 references, covering from 1956 to August 2022.

摘要

这篇综述对无碳取代基的天然部分还原的二萘嵌苯醌（PQs）（可命名为 A 类二萘嵌苯醌）的文献进行了批判性分析，并讨论了它们的结构、立体化学、生物合成和生物活性。二萘嵌苯醌是某些真菌、蚜虫、某些植物和动物产生的具有苝骨架的天然色素。这些化合物具有多种生物活性，如抗菌、抗 HIV、光增敏剂、细胞毒性和植物毒性。本文描述了 36 种真菌 PQs，并引用了 81 篇参考文献，涵盖了 1956 年至 2022 年 8 月的研究。