Overweg J, Binnie C D
Funct Neurol. 1986 Oct-Dec;1(4):539-41.
In view of the known role of Ca2+ in the paroxysmal depolarisation shifts of epileptic neurons, the possibility arises that certain Ca2+ entry blockers possess antiepileptic activity. The only drug of the class which readily passes blood-brain barrier is flunarizine. This is effective in experimental models of epilepsy and produced significant seizure reduction in two trials in therapy-resistant patients. Efficacy was maintained without development of tolerance. The safety of the drug has already been established in a great number of subjects treated for a long time for other diseases. It has few and mild side effects at therapeutic blood levels.
鉴于钙离子在癫痫神经元阵发性去极化漂移中的已知作用，某些钙离子通道阻滞剂具有抗癫痫活性的可能性随之而来。该类药物中唯一容易通过血脑屏障的是氟桂利嗪。它在癫痫实验模型中有效，并且在两项针对难治性患者的试验中显著减少了癫痫发作。疗效得以维持且未产生耐受性。该药物的安全性已在大量因其他疾病长期接受治疗的受试者中得到证实。在治疗血药浓度下，它的副作用少且轻微。
