Overweg J, Ashton D, de Beukelaar F, Binnie C D, Wauquier A, van Wieringen A
Eur Neurol. 1986;25 Suppl 1:93-101. doi: 10.1159/000116104.
In view of the known role of Ca2+ in the paroxysmal depolarization shifts of epileptic neurones, the possibility arises that certain Ca2+ entry blockers possess antiepileptic activity. The only drug of the class which readily passes the blood-brain barrier is flunarizine. This is effective in experimental models of epilepsy and produced significant seizure reduction in two therapeutic trials in therapy-resistant patients. It has few and mild side effects at therapeutic blood levels.
鉴于钙离子在癫痫神经元阵发性去极化偏移中所起的已知作用，某些钙离子通道阻滞剂具有抗癫痫活性的可能性随之出现。该类药物中唯一能轻易通过血脑屏障的是氟桂利嗪。它在癫痫实验模型中有效，并且在两项针对难治性患者的治疗试验中显著减少了癫痫发作。在治疗血药浓度时，它的副作用少且轻微。
