Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Department of Radiology, The Fourth People's Hospital of Harbin, Harbin, Heilongjiang, China.
PLoS One. 2022 Sep 13;17(9):e0274533. doi: 10.1371/journal.pone.0274533. eCollection 2022.
The volume of epicardial adipose tissue (EAT) is associated with an increased incidence of cardiovascular disease (CVD); however, only a few studies have examined its effect on the myocardial function of endurance in athletes. The association between the EAT and the variation of myocardial function is still unclear in amateur marathoners. Consequently, by using some sedentary individuals as the control, this study aims to evaluate the correlation between the EAT volume and the myocardial strain in the left and right ventricles of Chinese amateur marathoners by cardiac magnetic resonance (CMR).
A total of 30 amateur marathoners were included as the exercise group and 20 sedentary people as a control group. All participants received the cardiac magnetic resonance (CMR) to measure the left and right ventricular end-diastolic volume, end-systolic volume and volume index, stroke volume and index, cardiac output index, ejection fraction and myocardial mass, the EAT volume, global radial, circumferential, and longi-tudinal strains, and the strain rates of left and right ventricular myocardium.
There was a significant difference in the EAT volume (EATV) index between the exercise group and the control group (26.82±11.76ml/m2 vs 37.82±17.15ml/m2, P = 0.01). Results from the multivariate linear regression analysis showed that BMI (standardized β = 0.458; P < 0.001) had an independent positive correlation with the EATV index. The EATV index was negatively correlated with the left ventricular global radial strain (GRS) (r = -0.505; P = 0.004) in the exercise group, while it is negatively correlated with right ventricular GRS (r = -0.492; P = 0.027) and positively correlated with global longitudinal strain (GLS) (r = 0.601; P = 0.005) in the control group. In the exercise group, the multivariate linear regression analysis showed that the EATV index (standardized β = -0.429; P = 0.021) was an independent determinant of the left ventricular GRS, and being a male (standardized β = 0.396; P = 0.029) was an independent determinant of the right ventricular GLS.
The EATV index is independently correlated with the left ventricular GRS in the amateur Chinese marathoners, also, the amateur marathon reduces the EATV index and increases the left ventricular myocardial mass, which consequently reduces the adverse effects on myocardial function.
心外膜脂肪组织（EAT）的体积与心血管疾病（CVD）的发生率增加有关；然而，只有少数研究检查了它对运动员耐力心肌功能的影响。EAT 与业余马拉松运动员心肌功能变化之间的关系尚不清楚。因此，本研究通过心脏磁共振（CMR）以一些久坐的个体作为对照，旨在评估中国业余马拉松运动员左、右心室 EAT 体积与心肌应变之间的相关性。
共纳入 30 名业余马拉松运动员作为运动组，20 名久坐者作为对照组。所有参与者均接受心脏磁共振（CMR）检查，以测量左、右心室舒张末期容积、收缩末期容积和容积指数、每搏输出量和指数、心输出量指数、射血分数和心肌质量、EAT 体积、整体径向、圆周和长轴应变以及左、右心室心肌的应变率。
运动组和对照组之间的 EAT 体积（EATV）指数有显著差异（26.82±11.76ml/m2比 37.82±17.15ml/m2，P=0.01）。多元线性回归分析结果表明，BMI（标准化β=0.458；P<0.001）与 EATV 指数呈独立正相关。EATV 指数与运动组左心室整体径向应变（GRS）呈负相关（r=-0.505；P=0.004），与对照组右心室 GRS（r=-0.492；P=0.027）呈负相关，与整体纵向应变（GLS）（r=0.601；P=0.005）呈正相关。在运动组中，多元线性回归分析显示，EATV 指数（标准化β=-0.429；P=0.021）是左心室 GRS 的独立决定因素，男性（标准化β=0.396；P=0.029）是右心室 GLS 的独立决定因素。
EATV 指数与中国业余马拉松运动员的左心室 GRS 独立相关，业余马拉松运动员减少 EATV 指数并增加左心室心肌质量，从而降低对心肌功能的不良影响。
